| pubmed-article:9824291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C2697954 | lld:lifeskim |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C0026046 | lld:lifeskim |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C0085401 | lld:lifeskim |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C0085732 | lld:lifeskim |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C1446659 | lld:lifeskim |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C1879748 | lld:lifeskim |
| pubmed-article:9824291 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
| pubmed-article:9824291 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9824291 | pubmed:dateCreated | 1998-12-10 | lld:pubmed |
| pubmed-article:9824291 | pubmed:abstractText | Recently exonic and intronic mutations in the gene for microtubule-associated protein tau have been discovered in cases of familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Intronic mutations have been shown to lead to an abnormal preponderance of four-repeat tau isoforms. The effects of the exonic mutations are unknown. We report here that the G272V, P301L, V337M and R406W mutations lead to a marked reduction in the ability of tau to promote microtubule assembly. This partial loss-of-function may be the primary effect of the known missense mutations in tau. | lld:pubmed |
| pubmed-article:9824291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9824291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9824291 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9824291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9824291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9824291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9824291 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9824291 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:9824291 | pubmed:author | pubmed-author:SmithM JMJ | lld:pubmed |
| pubmed-article:9824291 | pubmed:author | pubmed-author:GoedertMM | lld:pubmed |
| pubmed-article:9824291 | pubmed:author | pubmed-author:HasegawaMM | lld:pubmed |
| pubmed-article:9824291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9824291 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:9824291 | pubmed:volume | 437 | lld:pubmed |
| pubmed-article:9824291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9824291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9824291 | pubmed:pagination | 207-10 | lld:pubmed |
| pubmed-article:9824291 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9824291 | pubmed:meshHeading | pubmed-meshheading:9824291-... | lld:pubmed |
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| pubmed-article:9824291 | pubmed:meshHeading | pubmed-meshheading:9824291-... | lld:pubmed |
| pubmed-article:9824291 | pubmed:meshHeading | pubmed-meshheading:9824291-... | lld:pubmed |
| pubmed-article:9824291 | pubmed:meshHeading | pubmed-meshheading:9824291-... | lld:pubmed |
| pubmed-article:9824291 | pubmed:meshHeading | pubmed-meshheading:9824291-... | lld:pubmed |
| pubmed-article:9824291 | pubmed:meshHeading | pubmed-meshheading:9824291-... | lld:pubmed |
| pubmed-article:9824291 | pubmed:meshHeading | pubmed-meshheading:9824291-... | lld:pubmed |
| pubmed-article:9824291 | pubmed:meshHeading | pubmed-meshheading:9824291-... | lld:pubmed |
| pubmed-article:9824291 | pubmed:meshHeading | pubmed-meshheading:9824291-... | lld:pubmed |
| pubmed-article:9824291 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9824291 | pubmed:articleTitle | Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly. | lld:pubmed |
| pubmed-article:9824291 | pubmed:affiliation | Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. | lld:pubmed |
| pubmed-article:9824291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9824291 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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