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pubmed-article:9824283pubmed:dateCreated1998-12-10lld:pubmed
pubmed-article:9824283pubmed:abstractTextNitration of phenolic compounds is a well-established mechanism on interaction with peroxynitrite. However, while nitration is the predominant reaction for monophenolic hydroxycinnamates, this does not take place with the catechol-containing hydroxycinnamate, caffeic acid. The aim of the present study was to investigate the mechanism of the chemical interaction of caffeic acid with peroxynitrite and to characterise the products formed. A novel compound was detected and characterised as the o-quinone of caffeic acid based on its reaction with nucleophilic thiol compounds, glutathione and L-cysteine. The same novel product was identified following the oxidation of caffeic acid in alkaline solutions confirming the identity of this species as a caffeic acid oxidation product.lld:pubmed
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pubmed-article:9824283pubmed:authorpubmed-author:Rice-EvansCClld:pubmed
pubmed-article:9824283pubmed:authorpubmed-author:KerryNNlld:pubmed
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pubmed-article:9824283pubmed:pagination167-71lld:pubmed
pubmed-article:9824283pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9824283pubmed:year1998lld:pubmed
pubmed-article:9824283pubmed:articleTitlePeroxynitrite oxidises catechols to o-quinones.lld:pubmed
pubmed-article:9824283pubmed:affiliationAntioxidant Research Centre, Guy's, King's College and St. Thomas's School of Biomedical Sciences, London, UK.lld:pubmed
pubmed-article:9824283pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9824283pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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