| pubmed-article:9821307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9821307 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9821307 | lifeskim:mentions | umls-concept:C1512658 | lld:lifeskim |
| pubmed-article:9821307 | lifeskim:mentions | umls-concept:C0597032 | lld:lifeskim |
| pubmed-article:9821307 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:9821307 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:9821307 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9821307 | pubmed:dateCreated | 1998-12-11 | lld:pubmed |
| pubmed-article:9821307 | pubmed:abstractText | We introduced two mutant genes (beige; bg that induces the deficiency of natural killer (NK) activity and xid that decreases the production of immunoglobulin) into KSN nude mice with high reproductive performances. We produced KSN bg/bg(nu/nu) (KSN-bg), KSN-xid/xid(nu/nn) (KSN-xid), KSN xid/xid,bg/bg(nu/nu) (KSN-BNX) and KSN-nu/+ (KS) mice by back-cross (cross-intercross method). All strains showed as high a reproductivity rate as the parental KSN mice. KSN-xid and KSN-BNX mice had a reduced percentage of B220 positive cells in the spleens compared to KSN and KSN-bg mice, but they showed increased percentages of Thy-1 and asialo GM1 positive cells. The serum immunoglobulin concentrations of KSN-BNX were as low as KSN-xid. Both KSN-bg and KSN-BNX mice showed deficient NK activity in spleens, whereas KSN-xid mice showed an elevated NK activity. Compared to nude mice, the growth of both human tumor cell TCO-1 and BxPc-3 transplanted subcutaneously was enhanced in KSN-BNX mice. However Panc-1 cells that was rejected in nude mice was not accepted in KSN-BNX mice. Liver metastasis of human pancreatic tumor cells; Capan-1, BxPc-3 and MIAPaCa-2 were studied. No significant difference was observed in the percentage of metastasis formed mice between nude and KSN-BNX mice. | lld:pubmed |
| pubmed-article:9821307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9821307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9821307 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9821307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9821307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9821307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9821307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9821307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9821307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9821307 | pubmed:issn | 0015-5632 | lld:pubmed |
| pubmed-article:9821307 | pubmed:author | pubmed-author:HashimotoNN | lld:pubmed |
| pubmed-article:9821307 | pubmed:author | pubmed-author:YasudaKK | lld:pubmed |
| pubmed-article:9821307 | pubmed:author | pubmed-author:NikaidoHH | lld:pubmed |
| pubmed-article:9821307 | pubmed:author | pubmed-author:HayakawaJ IJI | lld:pubmed |
| pubmed-article:9821307 | pubmed:author | pubmed-author:NikaidoOO | lld:pubmed |
| pubmed-article:9821307 | pubmed:author | pubmed-author:IshigakiYY | lld:pubmed |
| pubmed-article:9821307 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9821307 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:9821307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9821307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9821307 | pubmed:pagination | 493-4 | lld:pubmed |
| pubmed-article:9821307 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9821307 | pubmed:meshHeading | pubmed-meshheading:9821307-... | lld:pubmed |
| pubmed-article:9821307 | pubmed:meshHeading | pubmed-meshheading:9821307-... | lld:pubmed |
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| pubmed-article:9821307 | pubmed:meshHeading | pubmed-meshheading:9821307-... | lld:pubmed |
| pubmed-article:9821307 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9821307 | pubmed:articleTitle | Enhanced human tumor cell transplantability in a new congenic immunodeficient mouse; KSN-BNX. | lld:pubmed |
| pubmed-article:9821307 | pubmed:affiliation | Department of Radiation Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan. | lld:pubmed |
| pubmed-article:9821307 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9821307 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12229 | entrezgene:pubmed | pubmed-article:9821307 | lld:entrezgene |
| entrez-gene:15218 | entrezgene:pubmed | pubmed-article:9821307 | lld:entrezgene |
| entrez-gene:17101 | entrezgene:pubmed | pubmed-article:9821307 | lld:entrezgene |
