| pubmed-article:9819427 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9819427 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:9819427 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9819427 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9819427 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:9819427 | lifeskim:mentions | umls-concept:C0084785 | lld:lifeskim |
| pubmed-article:9819427 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9819427 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:9819427 | lifeskim:mentions | umls-concept:C0443264 | lld:lifeskim |
| pubmed-article:9819427 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9819427 | pubmed:dateCreated | 1998-12-24 | lld:pubmed |
| pubmed-article:9819427 | pubmed:abstractText | Thyroid transcription factor 1 (TTF-1) was identified for its critical role in thyroid-specific gene expression; its level in the thyroid is regulated by thyrotropin-increased cyclic AMP levels. TTF-1 was subsequently found in lung tissue, where it regulates surfactant expression, and in certain neural tissues, where its function is unknown. Ligands or signals regulating TTF-1 levels in lung or neural tissue are unknown. We recently identified TTF-1 in rat parafollicular C cells and parathyroid cells. In this report, we show that TTF-1 is present in the parafollicular C cells of multiple species and that it interacts with specific elements on the 5'-flanking regions of the extracellular Ca2+-sensing receptor (CaSR), calmodulin, and calcitonin genes in C cells. When intracellular Ca2+ levels are increased or decreased in C cells, by the calcium ionophore A23187, by physiologic concentrations of the P2 purinergic receptor ligand ATP, or by changes in extracellular Ca2+ levels, the promoter activity, RNA levels, and binding of TTF-1 to these genes are, respectively, decreased or increased. The changes in TTF-1 inversely alter CaSR gene and calcitonin gene expression. We show, therefore, that TTF-1 is a Ca2+-modulated transcription factor that coordinately regulates the activity of genes critical for Ca2+ homeostasis by parafollicular C cells. We hypothesize that TTF-1 similarly coordinates Ca2+-dependent gene expression in all cells in which TTF-1 and the CaSR are expressed, i. e., parathyroid cells, neural cells in the anterior pituitary or hippocampus, and keratinocytes. | lld:pubmed |
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| pubmed-article:9819427 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9819427 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9819427 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9819427 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9819427 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9819427 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9819427 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:9819427 | pubmed:author | pubmed-author:SuzukiKK | lld:pubmed |
| pubmed-article:9819427 | pubmed:author | pubmed-author:MoriAA | lld:pubmed |
| pubmed-article:9819427 | pubmed:author | pubmed-author:KohnL DLD | lld:pubmed |
| pubmed-article:9819427 | pubmed:author | pubmed-author:KimuraSS | lld:pubmed |
| pubmed-article:9819427 | pubmed:author | pubmed-author:OkajimaFF | lld:pubmed |
| pubmed-article:9819427 | pubmed:author | pubmed-author:KawaoiAA | lld:pubmed |
| pubmed-article:9819427 | pubmed:author | pubmed-author:KatohRR | lld:pubmed |
| pubmed-article:9819427 | pubmed:author | pubmed-author:LavaroniSS | lld:pubmed |
| pubmed-article:9819427 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9819427 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9819427 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9819427 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9819427 | pubmed:pagination | 7410-22 | lld:pubmed |
| pubmed-article:9819427 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
