| pubmed-article:9819366 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C1121402 | lld:lifeskim |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C0018131 | lld:lifeskim |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C0439590 | lld:lifeskim |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C2348628 | lld:lifeskim |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9819366 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9819366 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9819366 | pubmed:dateCreated | 1998-12-31 | lld:pubmed |
| pubmed-article:9819366 | pubmed:abstractText | Local production of immunosuppressive cytokines will be one of the most suitable therapeutic strategies against organ-specific autoimmune diabetes. To establish such a new therapy, we constructed recombinant adenoviral vectors with inserted mIL-12p40 (Ad.IL-12p40) and mIL-10 (Ad.IL-10). Sufficient amounts of IL-12p40 and IL-10 were secreted by relevant adenovirus-transfected nonobese diabetic (NOD) islets. Shortly after transfection, 400 NOD islets transfected with Ad.IL-12p40 or Ad.IL-10 were transplanted under the renal capsule of a newly diabetic NOD mouse. NOD mice with IL-12p40-producing islet grafts kept normoglycemia in all of 14 grafted mice for over 4 wk after transplantation. In contrast, NOD mice with IL-10-producing islet grafts became diabetic in all of six grafted mice within 2 wk af-ter transplantation. Reverse transcription-PCR analysis revealed that local production of IL-12p40 led to the decrease of interferon-gamma and the augmentation of transforming growth factor-beta at the graft site. These results suggest that IL-12 plays an important role in the destruction of islet cells at the inflamed site of autoimmunity. Such a local blockade of IL-12 would be a useful gene therapy for human autoimmune diabetes. | lld:pubmed |
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| pubmed-article:9819366 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9819366 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9819366 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9819366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9819366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9819366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9819366 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9819366 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9819366 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:YoshidaRR | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:YasudaHH | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:MoriyamaHH | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:HamadaHH | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:MikiMM | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:SaitoII | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:NagataMM | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:KasugaMM | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:OkamotoNN | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:YokonoKK | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:ArisawaKK | lld:pubmed |
| pubmed-article:9819366 | pubmed:author | pubmed-author:FujihiraKK | lld:pubmed |
| pubmed-article:9819366 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9819366 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9819366 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:9819366 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9819366 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9819366 | pubmed:pagination | 1807-14 | lld:pubmed |
| pubmed-article:9819366 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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