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pubmed-article:9816500pubmed:abstractTextThe authors investigated changes in the location and number of osteoclasts and their precursors during the development of articular lesions in type II collagen-induced arthritis in mice using tartrate-resistant acid phosphatase (TRAP) staining. The limb joints were examined at 6 to 15 weeks after the second immunization. The number of TRAP-positive cells increased as the articular lesions progressed. TRAP-positive macrophage-like cells were found in the hyperplastic synovial tissue and bone marrow stroma in the early stage. In the advanced stage, in addition to many TRAP-positive osteoclasts on the bone surface, TRAP-positive macrophage-like cells were observed in the pannus apart from the bone surface in the pannus-joint junctions. The above mentioned TRAP-positive macrophage-like cells are considered to be osteoclast precursors.lld:pubmed
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pubmed-article:9816500pubmed:authorpubmed-author:SuzukiMMlld:pubmed
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pubmed-article:9816500pubmed:pagination211-4lld:pubmed
pubmed-article:9816500pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:9816500pubmed:articleTitleChanges in location and number of tartrate-resistant acid phosphatase (TRAP)-positive cells during the development of type II collagen-induced arthritis in DBA/1J mice.lld:pubmed
pubmed-article:9816500pubmed:affiliationDepartment of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.lld:pubmed
pubmed-article:9816500pubmed:publicationTypeJournal Articlelld:pubmed