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pubmed-article:9815805pubmed:abstractTextThe spermine analogue N1,N11-diethylnorspermine (DENSPM) has been shown to induce the polyamine-acetylating enzyme spermidine/spermine N1-acetyltransferase, disrupt polyamine pool homeostasis, and inhibit tumor growth. DENSPM is currently being developed as an anti-neoplastic agent and is about to enter Phase II clinical trials. In this report, the antitumor efficacy of DENSPM was evaluated against a human transitional cell bladder BL13 carcinoma xenograft implanted orthotopically and s.c. in nude athymic mice. DENSPM was administered via continuous s.c. infusion at 93 mg/kg/day for 5 days. Treatment with DENSPM was well tolerated and produced tumor regressions in all mice with a significant proportion (up to 50%) of apparent cures. On the basis of low toxicity and good therapeutic efficacy, there is a strong rationale for evaluation of the therapeutic efficacy of DENSPM against bladder carcinomas in Phase II clinical trials.lld:pubmed
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pubmed-article:9815805pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9815805pubmed:articleTitleAntitumor efficacy of N1,N11-diethylnorspermine on a human bladder tumor xenograft in nude athymic mice.lld:pubmed
pubmed-article:9815805pubmed:affiliationGrace Cancer Drug Center and Division of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.lld:pubmed
pubmed-article:9815805pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9815805pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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