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pubmed-article:9813277pubmed:abstractTextHigh resolution magnetic resonance spectroscopy (MRS) of cerebrospinal fluid (CSF) is a non-destructive analytical method which allows rapid and simultaneous detection of molecules involved in intermediary and oxidative metabolic pathways. We developed a protocol suitable for routine MRS analysis of lyophilized CSF samples. This procedure guarantees sample integrity, from CSF collection to spectrum acquisition. MRS analysis of blood serum was included in our protocol as a complementary method to CSF analysis. This protocol can contribute to establish MRS of CSF as a new analytical tool to better understand the metabolic processes involved in neurological diseases.lld:pubmed
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pubmed-article:9813277pubmed:copyrightInfoCopyright 1998 Elsevier Science B.V.lld:pubmed
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pubmed-article:9813277pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9813277pubmed:articleTitleExperimental protocol for clinical analysis of cerebrospinal fluid by high resolution proton magnetic resonance spectroscopy.lld:pubmed
pubmed-article:9813277pubmed:affiliationCentre de Résonance Magnétique Biologique et Médicale, UMR CNRS 6612, Faculté de Médecine, 27 Bd Jean Moulin, F-13005, Marseille, France.lld:pubmed
pubmed-article:9813277pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9813277pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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