| pubmed-article:9811714 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9811714 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9811714 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:9811714 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9811714 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:9811714 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:9811714 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:9811714 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:9811714 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9811714 | pubmed:dateCreated | 1998-11-30 | lld:pubmed |
| pubmed-article:9811714 | pubmed:abstractText | Prevention of the initial infection of mucosal dendritic cells (DC) and interruption of the subsequent transmission of HIV-1 from DC to T cells are likely to be important attributes of an effective human immunodeficiency virus type 1 (HIV-1) vaccine. While anti-HIV-1 neutralizing antibodies have been difficult to elicit by immunization, there are several human monoclonal antibodies (MAbs) that effectively neutralize virus infection of activated T cells. We investigated the ability of three well-characterized neutralizing MAbs (IgG1b12, 2F5, and 2G12) to block HIV-1 infection of human DC. DC were generated from CD14(+) blood cells or obtained from cadaveric human skin. The MAbs prevented viral entry into purified DC and the ensuing productive infection in DC/T-cell cultures. When DC were first pulsed with HIV-1, MAbs blocked the subsequent transmission to unstimulated CD3(+) T cells. Thus, neutralizing antibodies can block HIV-1 infection of DC and the cell-to-cell transmission of virus from infected DC to T cells. These data suggest that neutralizing antibodies could interrupt the initial events associated with mucosal transmission and regional spread of HIV-1. | lld:pubmed |
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| pubmed-article:9811714 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9811714 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9811714 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9811714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9811714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9811714 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9811714 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9811714 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:BurtonD RDR | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:MichaelN LNL | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:PopeMM | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:SteinmanR MRM | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:BhardwajNN | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:KatingerHH | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:PatteeLL | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:CHUJ PJP | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:SHAWE JEJ | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:BirxD LDL | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:VanCottT CTC | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:MascolaJ RJR | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:FrankelS SSS | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:EhrenbergP... | lld:pubmed |
| pubmed-article:9811714 | pubmed:author | pubmed-author:LouderM KMK | lld:pubmed |
| pubmed-article:9811714 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9811714 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:9811714 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9811714 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9811714 | pubmed:pagination | 9788-94 | lld:pubmed |
| pubmed-article:9811714 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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