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pubmed-article:9807726pubmed:abstractTextIntestinal extramedullary plasmacytomas (EMPs) are rare tumours in dogs. Three cases of canine intestinal EMP with amyloid deposits are described in this report. These tumours, which were located in the rectal submucosa, had variable numbers of well-differentiated plasma cells and fewer multinucleated giant cells of plasmacytoid and histiocytic morphology, admixed with abundant amyloid. Two cases had metaplastic cartilage and bone within the amyloid deposits. Immunohistochemically, the plasma cells of all three tumours reacted for lambda-light chains of immunoglobulins but not for kappa-chains, indicating monoclonality. Plasma cells of two tumours were also positive to CD79a antiserum. Amyloid deposits were labelled with an A lambda (amyloid of immunoglobulin lambda-light chain origin) antiserum but not with antisera against its precursor protein, the immunoglobulin lambda-light chains, indicating possible conformational changes of amyloidogenic proteins during their transformation into amyloid.lld:pubmed
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pubmed-article:9807726pubmed:authorpubmed-author:MillerM AMAlld:pubmed
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pubmed-article:9807726pubmed:volume119lld:pubmed
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pubmed-article:9807726pubmed:pagination239-49lld:pubmed
pubmed-article:9807726pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9807726pubmed:articleTitleIntestinal multinodular A lambda-amyloid deposition associated with extramedullary plasmacytoma in three dogs: clinicopathological and immunohistochemical studies.lld:pubmed
pubmed-article:9807726pubmed:affiliationAnimal Health Diagnostic Laboratory, Michigan State University, East Lansing 48824, USA.lld:pubmed
pubmed-article:9807726pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9807726pubmed:publicationTypeCase Reportslld:pubmed
pubmed-article:9807726pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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