Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist.

Source:http://linkedlifedata.com/resource/pubmed/id/9804700

J. Med. Chem. 1998 Nov 5 41 23 4607-14

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PMID
9804700