| pubmed-article:9799233 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9799233 | lifeskim:mentions | umls-concept:C1705433 | lld:lifeskim |
| pubmed-article:9799233 | lifeskim:mentions | umls-concept:C0174045 | lld:lifeskim |
| pubmed-article:9799233 | lifeskim:mentions | umls-concept:C1366537 | lld:lifeskim |
| pubmed-article:9799233 | lifeskim:mentions | umls-concept:C1419227 | lld:lifeskim |
| pubmed-article:9799233 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:9799233 | lifeskim:mentions | umls-concept:C0288587 | lld:lifeskim |
| pubmed-article:9799233 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:9799233 | pubmed:dateCreated | 1999-1-11 | lld:pubmed |
| pubmed-article:9799233 | pubmed:abstractText | Neutrophils contain a soluble guanine-nucleotidebinding protein, made up of two components with molecular masses of 23 and 26 kDa, that mediates stimulation of phospholipase C-beta2 (PLCbeta2). We have identified the two components of the stimulatory heterodimer by amino acid sequencing as a Rho GTPase and the Rho guanine nucleotide dissociation inhibitor LyGDI. Using recombinant Rho GTPases and LyGDI, we demonstrate that PLCbeta2 is stimulated by guanosine 5'-O-(3-thiotriphosphate) (GTP[S])-activated Cdc42HsxLyGDI, but not by RhoAxLyGDI. Stimulation of PLCbeta2, which was also observed for GTP[S]-activated recombinant Rac1, was independent of LyGDI, but required C-terminal processing of Cdc42Hs/Rac1. Cdc42Hs/Rac1 also stimulated PLCbeta2 in a system made up of purified recombinant proteins, suggesting that this function is mediated by direct protein-protein interaction. The Cdc42Hs mutants F37A and Y40C failed to stimulate PLCbeta2, indicating that the Cdc42Hs effector site is involved in this interaction. The results identify PLCbeta2 as a novel effector of the Rho GTPases Cdc42Hs and Rac1, and as the first mammalian effector directly regulated by both heterotrimeric and low-molecular-mass GTP-binding proteins. | lld:pubmed |
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| pubmed-article:9799233 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9799233 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9799233 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9799233 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9799233 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9799233 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9799233 | pubmed:author | pubmed-author:MaierGG | lld:pubmed |
| pubmed-article:9799233 | pubmed:author | pubmed-author:DietrichAA | lld:pubmed |
| pubmed-article:9799233 | pubmed:author | pubmed-author:BinderWW | lld:pubmed |
| pubmed-article:9799233 | pubmed:author | pubmed-author:GierschikPP | lld:pubmed |
| pubmed-article:9799233 | pubmed:author | pubmed-author:SchwalbDD | lld:pubmed |
| pubmed-article:9799233 | pubmed:author | pubmed-author:IllenbergerDD | lld:pubmed |
| pubmed-article:9799233 | pubmed:author | pubmed-author:PimmerDD | lld:pubmed |
| pubmed-article:9799233 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9799233 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:9799233 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9799233 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9799233 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9799233 | pubmed:pagination | 6241-9 | lld:pubmed |
| pubmed-article:9799233 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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