| pubmed-article:9789010 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9789010 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9789010 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9789010 | lifeskim:mentions | umls-concept:C0035679 | lld:lifeskim |
| pubmed-article:9789010 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9789010 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9789010 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:9789010 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:9789010 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9789010 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:9789010 | pubmed:dateCreated | 1998-11-24 | lld:pubmed |
| pubmed-article:9789010 | pubmed:abstractText | Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis. Two pyrrole-imidazole polyamides were designed to bind DNA sequences immediately adjacent to binding sites for the transcription factors Ets-1, lymphoid-enhancer binding factor 1, and TATA-box binding protein. These synthetic ligands specifically inhibit DNA-binding of each transcription factor and HIV type 1 transcription in cell-free assays. When used in combination, the polyamides inhibit virus replication by >99% in isolated human peripheral blood lymphocytes, with no detectable cell toxicity. The ability of small molecules to target predetermined DNA sequences located within RNA polymerase II promoters suggests a general approach for regulation of gene expression, as well as a mechanism for the inhibition of viral replication. | lld:pubmed |
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| pubmed-article:9789010 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9789010 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9789010 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9789010 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9789010 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9789010 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9789010 | pubmed:author | pubmed-author:MosierD EDE | lld:pubmed |
| pubmed-article:9789010 | pubmed:author | pubmed-author:GottesfeldJ... | lld:pubmed |
| pubmed-article:9789010 | pubmed:author | pubmed-author:DervanP BPB | lld:pubmed |
| pubmed-article:9789010 | pubmed:author | pubmed-author:GuliziaR JRJ | lld:pubmed |
| pubmed-article:9789010 | pubmed:author | pubmed-author:DickinsonL... | lld:pubmed |
| pubmed-article:9789010 | pubmed:author | pubmed-author:BairdE EEE | lld:pubmed |
| pubmed-article:9789010 | pubmed:author | pubmed-author:TraugerJ WJW | lld:pubmed |
| pubmed-article:9789010 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9789010 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:9789010 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9789010 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9789010 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9789010 | pubmed:pagination | 12890-5 | lld:pubmed |
| pubmed-article:9789010 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9789010 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9789010 | pubmed:articleTitle | Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. | lld:pubmed |
| pubmed-article:9789010 | pubmed:affiliation | Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:9789010 | pubmed:publicationType | Journal Article | lld:pubmed |
