| pubmed-article:9788351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9788351 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:9788351 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9788351 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
| pubmed-article:9788351 | lifeskim:mentions | umls-concept:C0430054 | lld:lifeskim |
| pubmed-article:9788351 | lifeskim:mentions | umls-concept:C1705053 | lld:lifeskim |
| pubmed-article:9788351 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:9788351 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9788351 | pubmed:dateCreated | 1998-12-28 | lld:pubmed |
| pubmed-article:9788351 | pubmed:abstractText | The interaction of the N-type calcium channel beta3 subunit with the alpha1B subunit alters the activation/inactivation kinetics and the maximal conductance of the channel. The defined protein-protein interaction of the human alpha1B and beta3 subunits provides a target for small-molecule modulation of N-type channel activity. We describe a high throughput screen based on a counterselection yeast two-hybrid assay, which was used to identify small molecules that disrupt alpha1B-beta3 subunit interactions and inhibit N-type calcium channel activity. These small molecules may be a new class of calcium channel antagonists with therapeutic potential. | lld:pubmed |
| pubmed-article:9788351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9788351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9788351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788351 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9788351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9788351 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9788351 | pubmed:issn | 1087-0156 | lld:pubmed |
| pubmed-article:9788351 | pubmed:author | pubmed-author:LimRR | lld:pubmed |
| pubmed-article:9788351 | pubmed:author | pubmed-author:FrancoRR | lld:pubmed |
| pubmed-article:9788351 | pubmed:author | pubmed-author:LeaAA | lld:pubmed |
| pubmed-article:9788351 | pubmed:author | pubmed-author:SunLL | lld:pubmed |
| pubmed-article:9788351 | pubmed:author | pubmed-author:YoungKK | lld:pubmed |
| pubmed-article:9788351 | pubmed:author | pubmed-author:NORAEESr | lld:pubmed |
| pubmed-article:9788351 | pubmed:author | pubmed-author:HellingsSS | lld:pubmed |
| pubmed-article:9788351 | pubmed:author | pubmed-author:HusbandsMM | lld:pubmed |
| pubmed-article:9788351 | pubmed:author | pubmed-author:OzenbergerBB | lld:pubmed |
| pubmed-article:9788351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9788351 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:9788351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9788351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9788351 | pubmed:pagination | 946-50 | lld:pubmed |
| pubmed-article:9788351 | pubmed:dateRevised | 2004-12-31 | lld:pubmed |
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| pubmed-article:9788351 | pubmed:meshHeading | pubmed-meshheading:9788351-... | lld:pubmed |
| pubmed-article:9788351 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9788351 | pubmed:articleTitle | Identification of a calcium channel modulator using a high throughput yeast two-hybrid screen. | lld:pubmed |
| pubmed-article:9788351 | pubmed:affiliation | Wyeth-Ayerst Research, CNS Disorders, Princeton, NJ 08543, USA. | lld:pubmed |
| pubmed-article:9788351 | pubmed:publicationType | Journal Article | lld:pubmed |
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