| pubmed-article:9775393 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C0934502 | lld:lifeskim |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C0333463 | lld:lifeskim |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:9775393 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:9775393 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9775393 | pubmed:dateCreated | 1998-12-7 | lld:pubmed |
| pubmed-article:9775393 | pubmed:abstractText | Activated microglia overexpressing interleukin-1 (IL-1) are prominent neuropathological features of Alzheimer's disease. We used computerized image analysis to determine the number of IL-1 alpha-immunoreactive (IL-1 alpha +) microglia in cytoarchitectonic layers of parahippocampal gyrus (Brodmann's area 28) of Alzheimer and control patients. For cortical layers I and II, the numbers of IL-1 alpha + microglia were similar in Alzheimer and control patients. For layers III-VI, the numbers of IL-1 alpha + microglia were higher than that seen in layers I-II for both Alzheimer and control patients. Moreover, for layers III-VI, the number of IL-1 alpha + microglia in Alzheimer patients was significantly greater than that in control patients (relative Alzheimer values of threefold for layer III-V and twofold for layer VI; P < 0.05 in each case). The cortical laminar distribution of IL-1 alpha + microglia in Alzheimer patients correlated with the cortical laminar distribution of beta-amyloid precursor protein-immunoreactive (beta-APP+) neuritic plaques found in Alzheimer patients (r = 0.99, P < 0.005). Moreover, the cortical laminar distribution of IL-1 alpha + microglia in control patients also correlated with the cortical laminar distribution of beta-APP+ neuritic plaques found in Alzheimer patients (r = 0.91, P < 0.05). These correlations suggest that pre-existing laminar distribution patterns of IL-1 alpha + microglia (i.e. that seen in control patients) are important in determining the observed laminar distribution of beta-APP+ neuritic plaques in Alzheimer patients. These findings provide further support for our hypothesis that IL-1 is a key driving force in neuritic plaque formation in Alzheimer's disease. | lld:pubmed |
| pubmed-article:9775393 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9775393 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9775393 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9775393 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9775393 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9775393 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9775393 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9775393 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9775393 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9775393 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9775393 | pubmed:issn | 0305-1846 | lld:pubmed |
| pubmed-article:9775393 | pubmed:author | pubmed-author:GriffinW SWS | lld:pubmed |
| pubmed-article:9775393 | pubmed:author | pubmed-author:MrakR ERE | lld:pubmed |
| pubmed-article:9775393 | pubmed:author | pubmed-author:RoystonM CMC | lld:pubmed |
| pubmed-article:9775393 | pubmed:author | pubmed-author:ShengJ GJG | lld:pubmed |
| pubmed-article:9775393 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9775393 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:9775393 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9775393 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9775393 | pubmed:pagination | 278-83 | lld:pubmed |
| pubmed-article:9775393 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
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| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:meshHeading | pubmed-meshheading:9775393-... | lld:pubmed |
| pubmed-article:9775393 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9775393 | pubmed:articleTitle | Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease. | lld:pubmed |
| pubmed-article:9775393 | pubmed:affiliation | Geriatric Research, Education and Clinical Center, University of Arkansas for Medical Sciences, Little Rock, USA. | lld:pubmed |
| pubmed-article:9775393 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9775393 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9775393 | lld:pubmed |
