| pubmed-article:9769329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C0553662 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9769329 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9769329 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9769329 | pubmed:dateCreated | 1998-11-12 | lld:pubmed |
| pubmed-article:9769329 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9769329 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9769329 | pubmed:abstractText | During active disease, patients with systemic-onset juvenile chronic arthritis (S-JCA) demonstrate a rise and fall in serum interleukin-6 (IL-6) that parallels the classic quotidian fever. To investigate the possibility that this cytokine profile results from a difference in the control of IL-6 expression, we examined the 5' flanking region of the IL-6 gene for polymorphisms. A G/C polymorphism was detected at position -174. In a group of 383 healthy men and women from a general practice in North London, the frequency of the C allele was 0.403 (95% confidence interval 0.37-0.44). In comparison, 92 patients with S-JCA had a different overall genotype frequency, especially those with onset of disease at < 5 yr of age. This was mainly due to the statistically significant lower frequency of the CC genotype in this subgroup. When comparing constructs of the 5' flanking region (-550-+61 bp) in a luciferase reporter vector transiently transfected into HeLa cells, the -174C construct showed 0.624+/-0.15-fold lower expression than the -174G construct. After stimulation with LPS or IL-1, expression from the -174C construct did not significantly change after 24 h, whereas expression from the -174G construct increased by 2.35+/-0.10- and 3.60+/-0.26-fold, respectively, compared with the unstimulated level. Plasma levels of IL-6 were also measured in 102 of the healthy subjects, and the C allele was found to be associated with significantly lower levels of plasma IL-6. These results suggest that there is a genetically determined difference in the degree of the IL-6 response to stressful stimuli between individuals. The reduced frequency of the potentially protective CC genotype in young S-JCA patients may contribute to its pathogenesis. Similarly the individual's IL-6 genotype may be highly relevant in other conditions where IL-6 has been implicated, such as atherosclerosis. | lld:pubmed |
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| pubmed-article:9769329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9769329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9769329 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9769329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9769329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9769329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9769329 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9769329 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9769329 | pubmed:author | pubmed-author:YudkinJ SJS | lld:pubmed |
| pubmed-article:9769329 | pubmed:author | pubmed-author:WooPP | lld:pubmed |
| pubmed-article:9769329 | pubmed:author | pubmed-author:HumphriesSS | lld:pubmed |
| pubmed-article:9769329 | pubmed:author | pubmed-author:FishmanDD | lld:pubmed |
| pubmed-article:9769329 | pubmed:author | pubmed-author:JeffersHH | lld:pubmed |
| pubmed-article:9769329 | pubmed:author | pubmed-author:FauldsGG | lld:pubmed |
| pubmed-article:9769329 | pubmed:author | pubmed-author:Mohamed-AliVV | lld:pubmed |
| pubmed-article:9769329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9769329 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9769329 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:9769329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9769329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9769329 | pubmed:pagination | 1369-76 | lld:pubmed |
| pubmed-article:9769329 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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