| pubmed-article:9766450 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C0026900 | lld:lifeskim |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C0072473 | lld:lifeskim |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C1332710 | lld:lifeskim |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C1546856 | lld:lifeskim |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9766450 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9766450 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9766450 | pubmed:dateCreated | 1998-10-22 | lld:pubmed |
| pubmed-article:9766450 | pubmed:abstractText | CD34 is a cell-surface glycoprotein expressed in a developmental, stage-specific manner by bone marrow stem and progenitor cells. In this study we explored a possible role for c-Myb in CD34 regulation during developmental hematopoiesis. The results indicate that c-Myb can induce CD34 expression in hematopoietic and nonhematopoietic cells, and that murine CD34 promoter activity is enhanced in myeloid cells transgenic for c-Myb. To test whether c-Myb is necessary for CD34 expression during developmental hematopoiesis in vitro, c-Myb-null D3 embryonic stem (ES) cells were analyzed for their ability to develop CD34+ hematopoietic cells in vitro. CD34 promoter activity in transient transfections and CD34 upregulation during ES cell differentiation into embryoid bodies was identical in wild-type and c-Myb-null ES cells, indicating that c-Myb is not required for CD34 expression. CD34 protein is expressed on both hematopoietic and endothelial cells of the E8.5 blood islands during the development of c-Myb-null embryos, and expression is nearly identical in wild-type and c-Myb-null embryos. However, in E12.5 c-Myb-null embryos, the majority of identifiable CD34+ cells in the developing liver are endothelial rather than hematopoietic, which is consistent with the absence of colony-forming units in c-Myb-null embryos and developing ES cells. These data indicate that c-Myb is not required for CD34 expression in endothelial or primitive hematopoietic cells in the yolk sac, but is necessary for definitive hematopoiesis. | lld:pubmed |
| pubmed-article:9766450 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9766450 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9766450 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9766450 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9766450 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9766450 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9766450 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9766450 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9766450 | pubmed:issn | 0301-472X | lld:pubmed |
| pubmed-article:9766450 | pubmed:author | pubmed-author:MauW WWW | lld:pubmed |
| pubmed-article:9766450 | pubmed:author | pubmed-author:MucenskiM LML | lld:pubmed |
| pubmed-article:9766450 | pubmed:author | pubmed-author:KrauseD SDS | lld:pubmed |
| pubmed-article:9766450 | pubmed:author | pubmed-author:LawlerA MAM | lld:pubmed |
| pubmed-article:9766450 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9766450 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:9766450 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9766450 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9766450 | pubmed:pagination | 1086-92 | lld:pubmed |
| pubmed-article:9766450 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:meshHeading | pubmed-meshheading:9766450-... | lld:pubmed |
| pubmed-article:9766450 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9766450 | pubmed:articleTitle | CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb. | lld:pubmed |
| pubmed-article:9766450 | pubmed:affiliation | Johns Hopkins Oncology Center and Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, USA. | lld:pubmed |
| pubmed-article:9766450 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9766450 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9766450 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9766450 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12490 | entrezgene:pubmed | pubmed-article:9766450 | lld:entrezgene |
| entrez-gene:17863 | entrezgene:pubmed | pubmed-article:9766450 | lld:entrezgene |
