| pubmed-article:9765204 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C1335858 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C1336572 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C0008546 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:9765204 | lifeskim:mentions | umls-concept:C0753747 | lld:lifeskim |
| pubmed-article:9765204 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:9765204 | pubmed:dateCreated | 1998-11-16 | lld:pubmed |
| pubmed-article:9765204 | pubmed:abstractText | The promoter selectivity factor Sp1 often cooperates with other enhancer-binding proteins to activate transcription. To study the molecular underpinnings of these regulatory events, we have reconstituted in vitro the synergy observed in vivo between Sp1 and the sterol-regulated factor SREBP-1a at the low density lipoprotein receptor (LDLR) promoter. Using a highly purified human transcription system, we found that chromatin, TAFs, and a novel SREBP-binding coactivator activity, which includes CBP, are all required to mediate full synergistic activation by Sp1 and SREBP-1a. The SREBP-binding domain of CBP inhibits activation by SREBP-1a and Sp1 in a dominant-negative fashion that is both chromatin- and activator-specific. Whereas recombinant CBP alone is not sufficient to mediate activation, a human cellular fraction containing CBP can support high levels of chromatin-dependent synergistic activation. Purification of this activity to near homogeneity resulted in the identification of a multiprotein coactivator, including CBP, that selectively binds to the SREBP-1a activation domain and is capable of mediating high levels of synergistic activation by SREBP/Sp1 on chromatin templates. The development of a reconstituted chromatin transcription system has allowed us to isolate a novel coactivator that is recruited by the SREBP-1a activation domain and that functions in concert with TFIID to coordinate the action of multiple activators at complex promoters in the context of chromatin. | lld:pubmed |
| pubmed-article:9765204 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9765204 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9765204 | pubmed:status | MEDLINE | lld:pubmed |
