| pubmed-article:9763622 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9763622 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9763622 | lifeskim:mentions | umls-concept:C0596995 | lld:lifeskim |
| pubmed-article:9763622 | lifeskim:mentions | umls-concept:C0014994 | lld:lifeskim |
| pubmed-article:9763622 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:9763622 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:9763622 | pubmed:dateCreated | 1998-12-29 | lld:pubmed |
| pubmed-article:9763622 | pubmed:abstractText | 1. Two early signs of human myoblast commitment to fusion are membrane potential hyperpolarization and concomitant expression of a non-inactivating delayed rectifier K+ current, IK(NI). This current closely resembles the outward K+ current elicited by rat ether-à-go-go (r-eag) channels in its range of potential for activation and unitary conductance. 2. It is shown that activation kinetics of IK(NI), like those of r-eag, depend on holding potential and on [Mg2+]o, and that IK(NI), like r-eag, is reversibly inhibited by a rise in [Ca2+]i. 3. Forced expression of an isolated human ether-à-go-go K+ channel (h-eag) cDNA in undifferentiated myoblasts generates single-channel and whole-cell currents with remarkable similarity to IK(NI). 4. h-eag current (Ih-eag) is reversibly inhibited by a rise in [Ca2+]i, and the activation kinetics depend on holding potential and [Mg2+]o. 5. Forced expression of h-eag hyperpolarizes undifferentiated myoblasts from -9 to -50 mV, the threshold for the activation of both Ih-eag and IK(NI). Similarly, the higher the density of IK(NI), the more hyperpolarized the resting potential of fusion-competent myoblasts. 6. It is concluded that h-eag constitutes the channel underlying IK(NI) and that it contributes to the hyperpolarization of fusion-competent myoblasts. To our knowledge, this is the first demonstration of a physiological role for a mammalian eag K+ channel. | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9763622 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9763622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9763622 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9763622 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9763622 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:9763622 | pubmed:author | pubmed-author:LiuJ HJH | lld:pubmed |
| pubmed-article:9763622 | pubmed:author | pubmed-author:BaderC RCR | lld:pubmed |
| pubmed-article:9763622 | pubmed:author | pubmed-author:BernheimLL | lld:pubmed |
| pubmed-article:9763622 | pubmed:author | pubmed-author:OcchiodoroTT | lld:pubmed |
| pubmed-article:9763622 | pubmed:author | pubmed-author:Fischer-Lough... | lld:pubmed |
| pubmed-article:9763622 | pubmed:author | pubmed-author:BijlengaPP | lld:pubmed |
| pubmed-article:9763622 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9763622 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9763622 | pubmed:volume | 512 ( Pt 2) | lld:pubmed |
| pubmed-article:9763622 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9763622 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9763622 | pubmed:pagination | 317-23 | lld:pubmed |
| pubmed-article:9763622 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:meshHeading | pubmed-meshheading:9763622-... | lld:pubmed |
| pubmed-article:9763622 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9763622 | pubmed:articleTitle | An ether -à-go-go K+ current, Ih-eag, contributes to the hyperpolarization of human fusion-competent myoblasts. | lld:pubmed |
| pubmed-article:9763622 | pubmed:affiliation | Departement de Physiologie, Centre Medical Universitaire, Division de Recherche Clinique Neuro-Musculaire, Hopital Cantonal Universitaire, CH-1211 Geneva 4, Switzerland. | lld:pubmed |
| pubmed-article:9763622 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9763622 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9763622 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9763622 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9763622 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9763622 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9763622 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9763622 | lld:pubmed |
