| pubmed-article:9763433 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C1325742 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0010749 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C1705165 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0031164 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C2700061 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C2346927 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:9763433 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:9763433 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9763433 | pubmed:dateCreated | 1998-11-12 | lld:pubmed |
| pubmed-article:9763433 | pubmed:abstractText | Bcl-2 family members either promote or repress programmed cell death. Bax, a death-promoting member, is a pore-forming, mitochondria-associated protein whose mechanism of action is still unknown. During apoptosis, cytochrome C is released from the mitochondria into the cytosol where it binds to APAF-1, a mammalian homologue of Ced-4, and participates in the activation of caspases. The release of cytochrome C has been postulated to be a consequence of the opening of the mitochondrial permeability transition pore (PTP). We now report that Bax is sufficient to trigger the release of cytochrome C from isolated mitochondria. This pathway is distinct from the previously described calcium-inducible, cyclosporin A-sensitive PTP. Rather, the cytochrome C release induced by Bax is facilitated by Mg2+ and cannot be blocked by PTP inhibitors. These results strongly suggest the existence of two distinct mechanisms leading to cytochrome C release: one stimulated by calcium and inhibited by cyclosporin A, the other Bax dependent, Mg2+ sensitive but cyclosporin insensitive. | lld:pubmed |
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| pubmed-article:9763433 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9763433 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9763433 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9763433 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9763433 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:9763433 | pubmed:author | pubmed-author:RichterCC | lld:pubmed |
| pubmed-article:9763433 | pubmed:author | pubmed-author:MazzeiGG | lld:pubmed |
| pubmed-article:9763433 | pubmed:author | pubmed-author:NicholsAA | lld:pubmed |
| pubmed-article:9763433 | pubmed:author | pubmed-author:MartinotJ BJB | lld:pubmed |
| pubmed-article:9763433 | pubmed:author | pubmed-author:SadoulRR | lld:pubmed |
| pubmed-article:9763433 | pubmed:author | pubmed-author:EskerSS | lld:pubmed |
| pubmed-article:9763433 | pubmed:author | pubmed-author:AntonssonBB | lld:pubmed |
| pubmed-article:9763433 | pubmed:author | pubmed-author:MontessuitSS | lld:pubmed |
| pubmed-article:9763433 | pubmed:author | pubmed-author:Osen-SandAA | lld:pubmed |
| pubmed-article:9763433 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9763433 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:9763433 | pubmed:volume | 143 | lld:pubmed |
| pubmed-article:9763433 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9763433 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9763433 | pubmed:pagination | 217-24 | lld:pubmed |
| pubmed-article:9763433 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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