| pubmed-article:9759500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9759500 | lifeskim:mentions | umls-concept:C0682972 | lld:lifeskim |
| pubmed-article:9759500 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:9759500 | pubmed:dateCreated | 1998-11-30 | lld:pubmed |
| pubmed-article:9759500 | pubmed:abstractText | G protein-coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein-coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization. This review focuses on the regulation of GRK activity by a variety of allosteric and other factors: agonist-stimulated GPCRs, beta gamma subunits of heterotrimeric GTP-binding proteins, phospholipid cofactors, the calcium-binding proteins calmodulin and recoverin, posttranslational isoprenylation and palmitoylation, autophosphorylation, and protein kinase C-mediated GRK phosphorylation. Studies employing recombinant, purified proteins, cell culture, and transgenic animal models attest to the general importance of GRKs in regulating a vast array of GPCRs both in vitro and in vivo. | lld:pubmed |
| pubmed-article:9759500 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9759500 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9759500 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9759500 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9759500 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9759500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9759500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9759500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9759500 | pubmed:issn | 0066-4154 | lld:pubmed |
| pubmed-article:9759500 | pubmed:author | pubmed-author:LefkowitzR... | lld:pubmed |
| pubmed-article:9759500 | pubmed:author | pubmed-author:PitcherJ AJA | lld:pubmed |
| pubmed-article:9759500 | pubmed:author | pubmed-author:FreedmanN JNJ | lld:pubmed |
| pubmed-article:9759500 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9759500 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:9759500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9759500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9759500 | pubmed:pagination | 653-92 | lld:pubmed |
| pubmed-article:9759500 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:meshHeading | pubmed-meshheading:9759500-... | lld:pubmed |
| pubmed-article:9759500 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9759500 | pubmed:articleTitle | G protein-coupled receptor kinases. | lld:pubmed |
| pubmed-article:9759500 | pubmed:affiliation | Howard Hughes Medical Institute, Department of Medicine (Cardiology), Duke University Medical Center, Durham, North Carolina 27710, USA. pitch001@mc.duke.edu | lld:pubmed |
| pubmed-article:9759500 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9759500 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9759500 | pubmed:publicationType | Review | lld:pubmed |
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