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pubmed-article:9757076pubmed:abstractTextThe vagal postganglionic controls of cardiac rate and left ventricular contractility are mediated by separate intracardiac ganglia, the sino-atrial (SA) and cranio-ventricular (CV) ganglia, respectively. We injected a different retrograde tracer into each of these ganglia (in the same animal) and subsequently examined the brain for the presence of single labeled or double labeled vagal preganglionic neurons. Retrogradely labeled cells from either ganglion were found exclusively in the ventrolateral nucleus ambiguus (NA-VL). There was considerable overlap in the distribution of labeled cells from either ganglion, however fewer than 3% of labeled neurons were double labeled. The data are consistent with the hypothesis that the preganglionic controls of cardiac rate and left ventricular contractility are mediated by largely separate but overlapping groups of cardioinhibitory neurons originating from the NA-VL. These neurons have parallel but morphologically independent pathways projecting to the SA and CV ganglia. Physiological experiments are needed to support this hypothesis.lld:pubmed
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pubmed-article:9757076pubmed:authorpubmed-author:JohnsonT ATAlld:pubmed
pubmed-article:9757076pubmed:authorpubmed-author:BlinderK JKJlld:pubmed
pubmed-article:9757076pubmed:authorpubmed-author:John...lld:pubmed
pubmed-article:9757076pubmed:copyrightInfoCopyright 1998 Elsevier Science B.V.lld:pubmed
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pubmed-article:9757076pubmed:pagination325-30lld:pubmed
pubmed-article:9757076pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9757076pubmed:year1998lld:pubmed
pubmed-article:9757076pubmed:articleTitleNegative inotropic vagal preganglionic neurons in the nucleus ambiguus of the cat: neuroanatomical comparison with negative chronotropic neurons utilizing dual retrograde tracers.lld:pubmed
pubmed-article:9757076pubmed:affiliationDepartment of Pharmacology, Howard University College of Medicine, 520 W Street, NW, Washington, DC 20059, USA.lld:pubmed
pubmed-article:9757076pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9757076pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:9757076pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9757076pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed