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pubmed-article:9751364pubmed:abstractTextReports in the osteoporosis literature demonstrating the increased activity of specific alleles of the vitamin D receptor and epidemiological data linking vitamin D levels with prostate cancer have stimulated research into possible associations between vitamin D receptor genotype and the development of prostate cancer. Recent studies showed that patients homozygous for a less active vitamin D receptor have a 4 to 5 times increased risk of localized prostate cancer. In 1 study this association was strongest in patients with advanced disease. To understand better the relationship between advanced disease and the vitamin D receptor we compared the vitamin D receptor genotype of 41 patients who died of prostate cancer to 41 controls with no clinical evidence of prostate cancer.lld:pubmed
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pubmed-article:9751364pubmed:authorpubmed-author:IsaacsW BWBlld:pubmed
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pubmed-article:9751364pubmed:pagination1405-9lld:pubmed
pubmed-article:9751364pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9751364pubmed:year1998lld:pubmed
pubmed-article:9751364pubmed:articleTitleVitamin D receptor polymorphisms and lethal prostate cancer.lld:pubmed
pubmed-article:9751364pubmed:affiliationJames Buchanan Brady Urological Institute and Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.lld:pubmed
pubmed-article:9751364pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9751364pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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