pubmed-article:9739045 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C0282554 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:9739045 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:9739045 | pubmed:issue | 6 | lld:pubmed |
pubmed-article:9739045 | pubmed:dateCreated | 1998-10-13 | lld:pubmed |
pubmed-article:9739045 | pubmed:abstractText | The potential roles of CD8(+) T-cell-induced chemokines in the expansion of immune responses were examined using DNA immunogen constructs as model antigens. We coimmunized cDNA expression cassettes encoding the alpha-chemokines IL-8 and SDF-1alpha and the beta-chemokines MIP-1alpha, RANTES, and MCP-1 along with DNA immunogens and analyzed the resulting antigen-specific immune responses. In a manner more similar to the traditional immune modulatory role of CD4(+) T cells via the expression of Th1 or Th2 cytokines, CD8(+) T cells appeared to play an important role in immune expansion and effector function by producing chemokines. For instance, IL-8 was a strong inducer of CD4(+) T cells, indicated by strong T helper proliferative responses as well as an enhancement of antibody responses. MIP-1alpha had a dramatic effect on antibody responses and modulated the shift of immune responses to a Th2-type response. RANTES coimmunization enhanced the levels of antigen-specific Th1 and cytotoxic T lymphocyte (CTL) responses. Among the chemokines examined, MCP-1 was the most potent activator of CD8(+) CTL activity. The enhanced CTL results are supported by the increased expression of Th1 cytokines IFN-gamma and TNF-alpha and the reduction of IgG1/IgG2a ratio. Our results support that CD8(+) T cells may expand both humoral and cellular responses in vivo through the elaboration of specific chemokines at the peripheral site of infection during the effector stage of the immune response. | lld:pubmed |
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pubmed-article:9739045 | pubmed:language | eng | lld:pubmed |
pubmed-article:9739045 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9739045 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:9739045 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9739045 | pubmed:month | Sep | lld:pubmed |
pubmed-article:9739045 | pubmed:issn | 0021-9738 | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:WilsonD MDM | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:BennettMM | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:LEEM JMJJr | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:WeinerD BDB | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:ORRS HSH | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:KimJ JJJ | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:DanaMM | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:MorrisonLL | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:BoyerJ DJD | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:TsaiAA | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:AgadjanyanM... | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:ChalianA AAA | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:KazahayaKK | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:SinJ IJI | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:NottinghamL... | lld:pubmed |
pubmed-article:9739045 | pubmed:author | pubmed-author:DentchevTT | lld:pubmed |
pubmed-article:9739045 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9739045 | pubmed:day | 15 | lld:pubmed |
pubmed-article:9739045 | pubmed:volume | 102 | lld:pubmed |
pubmed-article:9739045 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9739045 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9739045 | pubmed:pagination | 1112-24 | lld:pubmed |
pubmed-article:9739045 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |