| pubmed-article:9736567 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0682458 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0001407 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0036043 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0348016 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9736567 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9736567 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9736567 | pubmed:dateCreated | 1998-10-22 | lld:pubmed |
| pubmed-article:9736567 | pubmed:abstractText | 9-[2-(R)-(Phosphonomethoxy)propyl]adenine (PMPA) is a nucleotide analogue with potent antiretroviral activity in vitro and in simian models. A randomized, double-blind, placebo-controlled, dose-escalation clinical trial of intravenous PMPA monotherapy was conducted in 20 human immunodeficiency virus (HIV)-infected adults with CD4 cell counts of >/=200 cells/mm3 and plasma HIV RNA levels of >/=10,000 copies/ml. Two dose levels were evaluated (1 and 3 mg/kg of body weight/day). Ten subjects were enrolled at each dose level (eight randomized to receive PMPA and two randomized to receive placebo). On day 1, a single dose of PMPA or placebo was administered by intravenous infusion. Beginning on study day 8, PMPA or placebo was administered once daily for an additional 7 consecutive days. All subjects tolerated dosing without significant adverse events. Mean peak serum PMPA concentrations were 2.7 +/- 0.9 and 9.1 +/- 2.1 microgram/ml in the 1- and 3-mg/kg cohorts, respectively. Serum concentrations declined in a biexponential fashion, with a terminal half-life of 4 to 8 h. At 3 mg/kg/day, a single infusion of PMPA resulted in a 0.4 log10 median decline in plasma HIV RNA by study day 8. Following 7 consecutive days of study drug administration thereafter, the median changes in plasma HIV RNA from baseline were -1.1, -0.6, and 0.1 log10 in the 3-mg/kg/day, 1-mg/kg/day, and placebo dose groups, respectively. Following the final dose in the 3-mg/kg/day cohort, the reduction in HIV RNA was sustained for 7 days before returning toward baseline. Further studies evaluating an oral prodrug of PMPA are under way. | lld:pubmed |
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| pubmed-article:9736567 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9736567 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736567 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9736567 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9736567 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9736567 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:9736567 | pubmed:author | pubmed-author:HwangFF | lld:pubmed |
| pubmed-article:9736567 | pubmed:author | pubmed-author:LietmanP SPS | lld:pubmed |
| pubmed-article:9736567 | pubmed:author | pubmed-author:RooneyJ FJF | lld:pubmed |
| pubmed-article:9736567 | pubmed:author | pubmed-author:KralV AVA | lld:pubmed |
| pubmed-article:9736567 | pubmed:author | pubmed-author:SafrinSS | lld:pubmed |
| pubmed-article:9736567 | pubmed:author | pubmed-author:CundyK CKC | lld:pubmed |
| pubmed-article:9736567 | pubmed:author | pubmed-author:HellmannN SNS | lld:pubmed |
| pubmed-article:9736567 | pubmed:author | pubmed-author:Barditch-Crov... | lld:pubmed |
| pubmed-article:9736567 | pubmed:author | pubmed-author:DeeksS GSG | lld:pubmed |
| pubmed-article:9736567 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9736567 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:9736567 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9736567 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9736567 | pubmed:pagination | 2380-4 | lld:pubmed |
| pubmed-article:9736567 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9736567 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9736567 | pubmed:articleTitle | Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults. | lld:pubmed |
| pubmed-article:9736567 | pubmed:affiliation | University of California, San Francisco, and San Francisco General Hospital, San Francisco, California, USA. sdeeks@sfaids.ucsf | lld:pubmed |
| pubmed-article:9736567 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9736567 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9736567 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:9736567 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:9736567 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
| pubmed-article:9736567 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
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