| pubmed-article:9736441 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C1166209 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C1538265 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C0599739 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9736441 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:9736441 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9736441 | pubmed:dateCreated | 1998-11-17 | lld:pubmed |
| pubmed-article:9736441 | pubmed:abstractText | This report demonstrates that in vitro activation of human cells with the beta-galactoside-specific lectin from mistletoe (ML-I) or interleukin-2 (IL-2) results in different patterns of activation and function of cytotoxic cells. It is now well established that natural killer (NK) and lymphokine-activated killer (LAK) cytotoxicity is mainly mediated by resting (NK) and IL-2-activated (LAK) CD56-positive (+) cells respectively. Culture of peripheral blood lymphocytes (PBL) for 3 days with ML-I led to expansion and activation of T cells which demonstrated NK- and LAK-like cytotoxicity. T lymphocyte subset analysis revealed that in total PBL, ML-I preferentially stimulated and expanded CD8+ T cells which mediated the cytotoxic effect. Incubation of highly purified CD8+ T cells alone with ML-I did not lead to induction of cytotoxicity, which required the presence of both CD4+ and CD14+ (monocytes) cells, suggesting that ML-I does not exert a direct effect on CD8+ T cells. Activation of PBL with both ML-I and IL-2 resulted in simultaneous induction of T and CD56+ cell-mediated NK and LAK cytotoxicity. These data suggest that treatment with ML-I and IL-2 might provide an approach to induce maximum cytotoxicity against tumors and to recruit both T and NK cells for tumor therapy. | lld:pubmed |
| pubmed-article:9736441 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9736441 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736441 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9736441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736441 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9736441 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9736441 | pubmed:issn | 0892-3973 | lld:pubmed |
| pubmed-article:9736441 | pubmed:author | pubmed-author:PapamichailMM | lld:pubmed |
| pubmed-article:9736441 | pubmed:author | pubmed-author:VoelterWW | lld:pubmed |
| pubmed-article:9736441 | pubmed:author | pubmed-author:StoevaSS | lld:pubmed |
| pubmed-article:9736441 | pubmed:author | pubmed-author:BaxevanisC... | lld:pubmed |
| pubmed-article:9736441 | pubmed:author | pubmed-author:GritzapisA... | lld:pubmed |
| pubmed-article:9736441 | pubmed:author | pubmed-author:ArsenisPP | lld:pubmed |
| pubmed-article:9736441 | pubmed:author | pubmed-author:TsitsilonisO... | lld:pubmed |
| pubmed-article:9736441 | pubmed:author | pubmed-author:SolerM HMH | lld:pubmed |
| pubmed-article:9736441 | pubmed:author | pubmed-author:VoutsasI FIF | lld:pubmed |
| pubmed-article:9736441 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9736441 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:9736441 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9736441 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9736441 | pubmed:pagination | 355-72 | lld:pubmed |
| pubmed-article:9736441 | pubmed:dateRevised | 2009-5-14 | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:meshHeading | pubmed-meshheading:9736441-... | lld:pubmed |
| pubmed-article:9736441 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9736441 | pubmed:articleTitle | Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity. | lld:pubmed |
| pubmed-article:9736441 | pubmed:affiliation | Cancer Immunology and Immunotherapy Center, St. Savas Cancer Hospital, Athens, Greece. | lld:pubmed |
| pubmed-article:9736441 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9736441 | lld:pubmed |
