| pubmed-article:9736428 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9736428 | lifeskim:mentions | umls-concept:C2673594 | lld:lifeskim |
| pubmed-article:9736428 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:9736428 | lifeskim:mentions | umls-concept:C1450035 | lld:lifeskim |
| pubmed-article:9736428 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:9736428 | pubmed:dateCreated | 1998-11-24 | lld:pubmed |
| pubmed-article:9736428 | pubmed:abstractText | This study examined clinical and inflammatory mediator parameters during the development of snuff-induced mucosal lesions. Nineteen smokeless tobacco (ST) users placed moist snuff at designated new placement sites over either a 2- or 7-day period. By day 2, the predominant clinical alteration was an erythematous reaction, and one-third of the subjects demonstrated white striations in combination with erythema or ulceration. By 7 days, 56% of the subjects displayed white striated lesions. Tissue concentrations (pg/mg) of IL-1beta were 4.6+/-1.6 at new placement sites as compared with 0.7+/-0.4 at control sites (P<0.05). PGE2 and IL-1alpha concentrations also were significantly higher (P<0.05) at new placement sites as compared with control sites (9.4+/-2.2 vs 4.1+/-0.7 and 6.2+/-1.3 vs 3.2+/-0.7, respectively). In view of the recognized role of PGE2 and IL-1 in immune and inflammatory functions, these mediators may play a role in the pathogenesis of clinical alterations at ST placement sites. | lld:pubmed |
| pubmed-article:9736428 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736428 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9736428 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736428 | pubmed:citationSubset | D | lld:pubmed |
| pubmed-article:9736428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9736428 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9736428 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9736428 | pubmed:issn | 0904-2512 | lld:pubmed |
| pubmed-article:9736428 | pubmed:author | pubmed-author:ReinhardtR... | lld:pubmed |
| pubmed-article:9736428 | pubmed:author | pubmed-author:JohnsonG KGK | lld:pubmed |
| pubmed-article:9736428 | pubmed:author | pubmed-author:PayneJ BJB | lld:pubmed |
| pubmed-article:9736428 | pubmed:author | pubmed-author:OrganC CCC | lld:pubmed |
| pubmed-article:9736428 | pubmed:author | pubmed-author:SlagerS LSL | lld:pubmed |
| pubmed-article:9736428 | pubmed:author | pubmed-author:FiliJ MJM | lld:pubmed |
| pubmed-article:9736428 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9736428 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:9736428 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9736428 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9736428 | pubmed:pagination | 388-94 | lld:pubmed |
| pubmed-article:9736428 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:meshHeading | pubmed-meshheading:9736428-... | lld:pubmed |
| pubmed-article:9736428 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9736428 | pubmed:articleTitle | Development of smokeless tobacco-induced oral mucosal lesions. | lld:pubmed |
| pubmed-article:9736428 | pubmed:affiliation | Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, USA. | lld:pubmed |
| pubmed-article:9736428 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9736428 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9736428 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
