| pubmed-article:9726441 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9726441 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:9726441 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:9726441 | lifeskim:mentions | umls-concept:C0079731 | lld:lifeskim |
| pubmed-article:9726441 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9726441 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:9726441 | lifeskim:mentions | umls-concept:C0015272 | lld:lifeskim |
| pubmed-article:9726441 | lifeskim:mentions | umls-concept:C1704419 | lld:lifeskim |
| pubmed-article:9726441 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:9726441 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:9726441 | pubmed:dateCreated | 1998-11-19 | lld:pubmed |
| pubmed-article:9726441 | pubmed:abstractText | Antibody (Ab)-based tumor therapeutics use the tumor-binding specificity of the Ab to target Fc functions or associated molecules to the site of the tumor. We have used an Ab-interleukin-2 (IL-2) fusion protein to deliver IL-2 to a murine B cell lymphoma (38C13). This anti-Id IgG3-CH3-IL-2, which recognizes the idiotype present on the surface of the lymphoma has a half-life in mice approximately 17-fold longer than the half-life reported for IL-2. Gamma camera studies showed that anti-Id IgG3-CH3-IL-2 localizes at the site of a subcutaneous tumor in mice. The anti-Id IgG3-CH3-IL-2 also shows enhanced antitumor activity compared with the combination of Ab and IL-2 administered together. However, the mechanism of antitumor activity appears to depend on the dose and the treatment schedule used. A single dose of fusion protein prevented tumor in only 50% of the animals, although all the survivors showed some evidence of immunologic memory. Although multiple doses are more effective in preventing tumor growth (87% survivors), they are ineffective in generating protective immunologic memory. Our results suggest that Ab-IL-2 fusion proteins will be useful in the diagnosis and treatment of human B cell lymphomas and other related malignancies. | lld:pubmed |
| pubmed-article:9726441 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9726441 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9726441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9726441 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9726441 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9726441 | pubmed:issn | 1079-9907 | lld:pubmed |
| pubmed-article:9726441 | pubmed:author | pubmed-author:MorrisonS LSL | lld:pubmed |
| pubmed-article:9726441 | pubmed:author | pubmed-author:PenichetM LML | lld:pubmed |
| pubmed-article:9726441 | pubmed:author | pubmed-author:HarvillE TET | lld:pubmed |
| pubmed-article:9726441 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9726441 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9726441 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9726441 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9726441 | pubmed:pagination | 597-607 | lld:pubmed |
| pubmed-article:9726441 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9726441 | pubmed:meshHeading | pubmed-meshheading:9726441-... | lld:pubmed |
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| pubmed-article:9726441 | pubmed:meshHeading | pubmed-meshheading:9726441-... | lld:pubmed |
| pubmed-article:9726441 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9726441 | pubmed:articleTitle | An IgG3-IL-2 fusion protein recognizing a murine B cell lymphoma exhibits effective tumor imaging and antitumor activity. | lld:pubmed |
| pubmed-article:9726441 | pubmed:affiliation | Department of Microbiology and Molecular Genetics, Molecular Biology Institute, University of California, Los Angeles 90095-1489, USA. | lld:pubmed |
| pubmed-article:9726441 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9726441 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9726441 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
