| pubmed-article:9719058 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9719058 | lifeskim:mentions | umls-concept:C0001779 | lld:lifeskim |
| pubmed-article:9719058 | lifeskim:mentions | umls-concept:C0206162 | lld:lifeskim |
| pubmed-article:9719058 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:9719058 | lifeskim:mentions | umls-concept:C0235248 | lld:lifeskim |
| pubmed-article:9719058 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:9719058 | lifeskim:mentions | umls-concept:C0553534 | lld:lifeskim |
| pubmed-article:9719058 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9719058 | pubmed:dateCreated | 1998-9-9 | lld:pubmed |
| pubmed-article:9719058 | pubmed:abstractText | Based on observations of smaller increases in limb vascular resistance during acute incremental hypovolemia in older adults, cardiopulmonary and integrative (combined cardiopulmonary and arterial) baroreflex control of sympatho-circulatory function is thought to be impaired with aging in humans. We tested this hypothesis directly by making intraneural measurements of skeletal muscle sympathetic nerve activity (MSNA; peroneal microneurography) in groups of young (23+/-1 years; n=11) and older (64+/-1 years; n=12) healthy adult men during progressive hypovolemia produced by graded (-5 to -40 mm Hg) lower body negative pressure (LBNP). Baseline levels of MSNA and arterial blood pressure were higher and heart rate was lower in the older subjects (P<0.05). Lower levels of LBNP (-5 to -20 mm Hg) did not affect arterial blood pressure or heart rate in either group; systolic and pulse pressures declined during higher levels of LBNP (-30 and -40 mm Hg) but only in the young subjects (P<0.05). Graded LBNP evoked progressive, linear reductions in peripheral venous pressure (PVP) and increases in MSNA, plasma norepinephrine concentration (PNE), and forearm vascular resistance (FVR) in both groups (all P<0.05). DeltaMSNA/ deltaPVP was approximately 150% greater in the older versus young men during both lower and higher levels of hypovolemia (P<0.01); however, deltaFVR/deltaPVP was approximately 50% smaller in the older men (P<0.05). There was no difference in the MSNA-PNE relation with age, but deltaFVR/deltaMSNA was approximately 65% to 70% smaller in the older subjects (P<0.05). Our findings indicate that cardiopulmonary and integrative baroreflex control of central sympathetic outflow during hypovolemia is augmented, not impaired, with age in healthy humans. However, the reflex-mediated increases in limb vascular resistance during hypovolemia are smaller in older adults because of attenuated vasoconstrictor responsiveness to sympathetic stimulation. | lld:pubmed |
| pubmed-article:9719058 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9719058 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9719058 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9719058 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9719058 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9719058 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9719058 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9719058 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9719058 | pubmed:issn | 0194-911X | lld:pubmed |
| pubmed-article:9719058 | pubmed:author | pubmed-author:TanakaHH | lld:pubmed |
| pubmed-article:9719058 | pubmed:author | pubmed-author:SealsD RDR | lld:pubmed |
| pubmed-article:9719058 | pubmed:author | pubmed-author:DaweK EKE | lld:pubmed |
| pubmed-article:9719058 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9719058 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:9719058 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9719058 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9719058 | pubmed:pagination | 298-304 | lld:pubmed |
| pubmed-article:9719058 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9719058 | pubmed:meshHeading | pubmed-meshheading:9719058-... | lld:pubmed |
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| pubmed-article:9719058 | pubmed:meshHeading | pubmed-meshheading:9719058-... | lld:pubmed |
| pubmed-article:9719058 | pubmed:meshHeading | pubmed-meshheading:9719058-... | lld:pubmed |
| pubmed-article:9719058 | pubmed:meshHeading | pubmed-meshheading:9719058-... | lld:pubmed |
| pubmed-article:9719058 | pubmed:meshHeading | pubmed-meshheading:9719058-... | lld:pubmed |
| pubmed-article:9719058 | pubmed:meshHeading | pubmed-meshheading:9719058-... | lld:pubmed |
| pubmed-article:9719058 | pubmed:meshHeading | pubmed-meshheading:9719058-... | lld:pubmed |
| pubmed-article:9719058 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9719058 | pubmed:articleTitle | Augmented cardiopulmonary and integrative sympathetic baroreflexes but attenuated peripheral vasoconstriction with age. | lld:pubmed |
| pubmed-article:9719058 | pubmed:affiliation | Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology, University of Colorado at Boulder, USA. davy@cahs.colostate.edu | lld:pubmed |
| pubmed-article:9719058 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9719058 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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