| pubmed-article:9718130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9718130 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9718130 | lifeskim:mentions | umls-concept:C0497327 | lld:lifeskim |
| pubmed-article:9718130 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:9718130 | lifeskim:mentions | umls-concept:C0238607 | lld:lifeskim |
| pubmed-article:9718130 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:9718130 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:9718130 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:9718130 | lifeskim:mentions | umls-concept:C0961954 | lld:lifeskim |
| pubmed-article:9718130 | lifeskim:mentions | umls-concept:C1100939 | lld:lifeskim |
| pubmed-article:9718130 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9718130 | pubmed:dateCreated | 1998-11-3 | lld:pubmed |
| pubmed-article:9718130 | pubmed:abstractText | HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia, brain-derived tat, env, and pol sequences were examined from AIDS patients defined pre-mortem as demented (HIV-D)[n=5] or non-demented (HIV-ND)[n=5]. Estimations of evolutionary distances and frequency of non-synonymous mutation rates revealed significant differences between brain-derived tat, env, and pol-encoded reverse transcriptase sequences. However, established zidovudine-associated resistance mutations in reverse transcriptase sequences were identified in only one HIV-D and one HIV-ND patient despite prolonged treatment of some patients. Non-synonymous/synonymous substitution rates among the tat sequences derived from patients with HIV-D were significantly higher compared to the HIV-ND group (P < 0.001). The ratios of transversions to transitions were also significantly higher among the HIV-D tat sequences (P< 0.01). Phylogenetic analyses showed clustering of sequences from each clinical group among the brain-derived tat and env sequences. These studies indicated that differing selective forces act on individual HIV-1 genes in the brain which may influence the development of dementia. | lld:pubmed |
| pubmed-article:9718130 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9718130 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9718130 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9718130 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9718130 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9718130 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9718130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9718130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9718130 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9718130 | pubmed:issn | 1355-0284 | lld:pubmed |
| pubmed-article:9718130 | pubmed:author | pubmed-author:LisMM | lld:pubmed |
| pubmed-article:9718130 | pubmed:author | pubmed-author:GlassJ DJD | lld:pubmed |
| pubmed-article:9718130 | pubmed:author | pubmed-author:KlassenG AGA | lld:pubmed |
| pubmed-article:9718130 | pubmed:author | pubmed-author:PowerCC | lld:pubmed |
| pubmed-article:9718130 | pubmed:author | pubmed-author:McArthurJ CJC | lld:pubmed |
| pubmed-article:9718130 | pubmed:author | pubmed-author:BratanichA... | lld:pubmed |
| pubmed-article:9718130 | pubmed:author | pubmed-author:FudykTT | lld:pubmed |
| pubmed-article:9718130 | pubmed:author | pubmed-author:MittooSS | lld:pubmed |
| pubmed-article:9718130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9718130 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:9718130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9718130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9718130 | pubmed:pagination | 387-93 | lld:pubmed |
| pubmed-article:9718130 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:meshHeading | pubmed-meshheading:9718130-... | lld:pubmed |
| pubmed-article:9718130 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9718130 | pubmed:articleTitle | Brain-derived HIV-1 tat sequences from AIDS patients with dementia show increased molecular heterogeneity. | lld:pubmed |
| pubmed-article:9718130 | pubmed:affiliation | Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada. | lld:pubmed |
| pubmed-article:9718130 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9718130 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9718130 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9718130 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9718130 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9718130 | lld:pubmed |
