Linked Life Data

9717976

Source:http://linkedlifedata.com/resource/pubmed/id/9717976

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9717976rdf:typepubmed:Citationlld:pubmed
pubmed-article:9717976lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C0025926lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C1704256lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C0022663lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C0178664lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C1533698lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C0205216lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C1515406lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C1515670lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C0392756lld:lifeskim
pubmed-article:9717976lifeskim:mentionsumls-concept:C0282774lld:lifeskim
pubmed-article:9717976pubmed:issue2lld:pubmed
pubmed-article:9717976pubmed:dateCreated1998-9-9lld:pubmed
pubmed-article:9717976pubmed:abstractTextOver-expression of iNOS is implicated in the pathogenesis of glomerulonephritis in animal models of systemic lupus erythematosus. The aim of this study was to evaluate the effect of aminoguanidine, a selective inhibitor of iNOS, for the protection from glomerulosclerosis in NZB/W F1 mice. Female NZB/W F1 mice (n = 8) were treated with aminoguanidine (1 g/l) in drinking water for 4 months starting at age 2 months before the onset of glomerulonephritis. Controls were age- and sex-matched mice (n = 10) without aminoguanidine treatment. By glomerular microdissection and reverse-transcription competitive polymerase chain reaction, we found that glomerular iNOS/beta-actin and TGF-beta1/beta-actin mRNA ratios were reduced 15.1% (P<0.05) and 61.3% (P<0.01), respectively, in aminoguanidine-treated mice. Aminoguanidine significantly reduced the glomerular iNOS staining, urinary nitrite production and degree of glomerulosclerosis. In addition, the glomerular volume and mean glomerular cell number were reduced 33.2% (P<0.01) and 32.8% (P<0.01), respectively. Likewise, the urinary proteinuria was also significantly reduced by aminoguanidine. These results indicate that administration of aminoguanidine may reduce the progression of glomerulosclerosis in NZB/W F1 mice, possibly through inhibition of glomerular nitric oxide production.lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:languageenglld:pubmed
pubmed-article:9717976pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:citationSubsetIMlld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9717976pubmed:statusMEDLINElld:pubmed
pubmed-article:9717976pubmed:monthAuglld:pubmed
pubmed-article:9717976pubmed:issn0009-9104lld:pubmed
pubmed-article:9717976pubmed:authorpubmed-author:YuC CCClld:pubmed
pubmed-article:9717976pubmed:authorpubmed-author:HuangC CCClld:pubmed
pubmed-article:9717976pubmed:authorpubmed-author:OhY HYHlld:pubmed
pubmed-article:9717976pubmed:authorpubmed-author:YangC WCWlld:pubmed
pubmed-article:9717976pubmed:issnTypePrintlld:pubmed
pubmed-article:9717976pubmed:volume113lld:pubmed
pubmed-article:9717976pubmed:ownerNLMlld:pubmed
pubmed-article:9717976pubmed:authorsCompleteYlld:pubmed
pubmed-article:9717976pubmed:pagination258-64lld:pubmed
pubmed-article:9717976pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
pubmed-article:9717976pubmed:meshHeadingpubmed-meshheading:9717976-...lld:pubmed
More...