| pubmed-article:9716402 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9716402 | lifeskim:mentions | umls-concept:C0044602 | lld:lifeskim |
| pubmed-article:9716402 | lifeskim:mentions | umls-concept:C0285558 | lld:lifeskim |
| pubmed-article:9716402 | lifeskim:mentions | umls-concept:C1705328 | lld:lifeskim |
| pubmed-article:9716402 | lifeskim:mentions | umls-concept:C1705341 | lld:lifeskim |
| pubmed-article:9716402 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:9716402 | lifeskim:mentions | umls-concept:C0812228 | lld:lifeskim |
| pubmed-article:9716402 | lifeskim:mentions | umls-concept:C1416458 | lld:lifeskim |
| pubmed-article:9716402 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9716402 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:9716402 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:9716402 | pubmed:dateCreated | 1998-9-16 | lld:pubmed |
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| pubmed-article:9716402 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716402 | pubmed:abstractText | A neurosecretory pathway regulates a reversible developmental arrest and metabolic shift at the Caenorhabditis elegans dauer larval stage. Defects in an insulin-like signaling pathway cause arrest at the dauer stage. We show here that two C. elegans Akt/PKB homologs, akt-1 and akt-2, transduce insulin receptor-like signals that inhibit dauer arrest and that AKT-1 and AKT-2 signaling are indispensable for insulin receptor-like signaling in C. elegans. A loss-of-function mutation in the Fork head transcription factor DAF-16 relieves the requirement for Akt/PKB signaling, which indicates that AKT-1 and AKT-2 function primarily to antagonize DAF-16. This is the first evidence that the major target of Akt/PKB signaling is a transcription factor. An activating mutation in akt-1, revealed by a genetic screen, as well as increased dosage of wild-type akt-1 relieves the requirement for signaling from AGE-1 PI3K, which acts downstream of the DAF-2 insulin/IGF-1 receptor homolog. This demonstrates that Akt/PKB activity is not necessarily dependent on AGE-1 PI3K activity. akt-1 and akt-2 are expressed in overlapping patterns in the nervous system and in tissues that are remodeled during dauer formation. | lld:pubmed |
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| pubmed-article:9716402 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9716402 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716402 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9716402 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9716402 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9716402 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:9716402 | pubmed:author | pubmed-author:RuvkunGG | lld:pubmed |
| pubmed-article:9716402 | pubmed:author | pubmed-author:ParadisSS | lld:pubmed |
| pubmed-article:9716402 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9716402 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9716402 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:9716402 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9716402 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9716402 | pubmed:pagination | 2488-98 | lld:pubmed |
| pubmed-article:9716402 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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