| pubmed-article:9716347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0023185 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0003779 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0233794 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0078939 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C1708096 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:9716347 | lifeskim:mentions | umls-concept:C0758714 | lld:lifeskim |
| pubmed-article:9716347 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:9716347 | pubmed:dateCreated | 1998-11-4 | lld:pubmed |
| pubmed-article:9716347 | pubmed:abstractText | We have reported that the continuous infusion of beta-amyloid protein-(1-40) into the rat cerebral ventricle produces learning and memory deficits accompanied by dysfunction in the cholinergic and dopaminergic systems. L-Pyroglutamyl-L-asparaginyl-L-seryl-L-prolyl-L-arginylglycinamide (NC-1900), an active fragment analog of arginine vasopressin in the rat brain, is a stable peptide with a five-fold longer half-life than that of arginine vasopressin-(4-9). In the present study, we examined the effects of NC-1900 on learning and memory deficits in beta-amyloid protein-(1-40)-infused rats. The rats were injected subcutaneously with NC-1900 (0.1 and 1 ng kg(-1)) once a day throughout the period of behavioral examination. In the beta-amyloid protein-infused rats, learning and memory in water maze and passive avoidance tasks were impaired compared with these in the control rats. NC-1900 prevented the learning and memory deficits in beta-amyloid protein-infused rats. Moreover, NC-1900 tended to increase the choline acetyltransferase activity in the frontal cortex of the beta-amyloid protein-infused rats. These results suggested that NC-1900 could be useful for the treatment of patients with Alzheimer's disease. | lld:pubmed |
| pubmed-article:9716347 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9716347 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716347 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9716347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9716347 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9716347 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:9716347 | pubmed:author | pubmed-author:YamadaKK | lld:pubmed |
| pubmed-article:9716347 | pubmed:author | pubmed-author:TanakaTT | lld:pubmed |
| pubmed-article:9716347 | pubmed:author | pubmed-author:NishimuraKK | lld:pubmed |
| pubmed-article:9716347 | pubmed:author | pubmed-author:KameyamaTT | lld:pubmed |
| pubmed-article:9716347 | pubmed:author | pubmed-author:NabeshimaTT | lld:pubmed |
| pubmed-article:9716347 | pubmed:author | pubmed-author:NarimatsuHH | lld:pubmed |
| pubmed-article:9716347 | pubmed:author | pubmed-author:SenzakiKK | lld:pubmed |
| pubmed-article:9716347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9716347 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:9716347 | pubmed:volume | 352 | lld:pubmed |
| pubmed-article:9716347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9716347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9716347 | pubmed:pagination | 135-42 | lld:pubmed |
| pubmed-article:9716347 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9716347 | pubmed:meshHeading | pubmed-meshheading:9716347-... | lld:pubmed |
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| pubmed-article:9716347 | pubmed:meshHeading | pubmed-meshheading:9716347-... | lld:pubmed |
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| pubmed-article:9716347 | pubmed:meshHeading | pubmed-meshheading:9716347-... | lld:pubmed |
| pubmed-article:9716347 | pubmed:meshHeading | pubmed-meshheading:9716347-... | lld:pubmed |
| pubmed-article:9716347 | pubmed:meshHeading | pubmed-meshheading:9716347-... | lld:pubmed |
| pubmed-article:9716347 | pubmed:meshHeading | pubmed-meshheading:9716347-... | lld:pubmed |
| pubmed-article:9716347 | pubmed:meshHeading | pubmed-meshheading:9716347-... | lld:pubmed |
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| pubmed-article:9716347 | pubmed:meshHeading | pubmed-meshheading:9716347-... | lld:pubmed |
| pubmed-article:9716347 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9716347 | pubmed:articleTitle | NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by beta-amyloid protein in rats. | lld:pubmed |
| pubmed-article:9716347 | pubmed:affiliation | Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:9716347 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9716347 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9716347 | lld:pubmed |
