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| pubmed-article:9714828 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:9714828 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:9714828 | lifeskim:mentions | umls-concept:C0011519 | lld:lifeskim |
| pubmed-article:9714828 | lifeskim:mentions | umls-concept:C0014230 | lld:lifeskim |
| pubmed-article:9714828 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9714828 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9714828 | pubmed:dateCreated | 1998-10-1 | lld:pubmed |
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| pubmed-article:9714828 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9714828 | pubmed:abstractText | We have cloned human and murine DNase I-like cDNAs, termed LS-DNase, which are expressed at high levels in liver and spleen tissues. LS-DNase expression is highly specific to macrophage populations within these and other tissues. Mature LS-DNase from both species is a secreted, non-glycosylated protein containing 285 residues, with a calculated molecular mass of 33 kDa and a basic isoelectric point. Human and murine LS-DNase are highly conserved and share 83% identity. Sequence analysis reveals that LS-DNase shares 46% amino acid sequence identity with DNase I. However, several residues identified as important for interaction of human DNase I with actin are not conserved in both human and murine LS-DNase. Consistent with this observation, recombinant human LS-DNase possesses a DNA hydrolytic activity which, unlike DNase I, is not inhibited by G-actin. The existence of a family of DNase I-like molecules that have tissue-specific expression patterns and the possible role of a macrophage specific DNase are discussed. | lld:pubmed |
| pubmed-article:9714828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9714828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9714828 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9714828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9714828 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9714828 | pubmed:issn | 0378-1119 | lld:pubmed |
| pubmed-article:9714828 | pubmed:author | pubmed-author:SpencerS ASA | lld:pubmed |
| pubmed-article:9714828 | pubmed:author | pubmed-author:LazarusR ARA | lld:pubmed |
| pubmed-article:9714828 | pubmed:author | pubmed-author:BakerK PKP | lld:pubmed |
| pubmed-article:9714828 | pubmed:author | pubmed-author:PanC QCQ | lld:pubmed |
| pubmed-article:9714828 | pubmed:author | pubmed-author:URKAII | lld:pubmed |
| pubmed-article:9714828 | pubmed:author | pubmed-author:BaronW FWF | lld:pubmed |
| pubmed-article:9714828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9714828 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:9714828 | pubmed:volume | 215 | lld:pubmed |
| pubmed-article:9714828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9714828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9714828 | pubmed:pagination | 291-301 | lld:pubmed |
| pubmed-article:9714828 | pubmed:dateRevised | 2004-11-18 | lld:pubmed |
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| pubmed-article:9714828 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9714828 | pubmed:articleTitle | Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. | lld:pubmed |
| pubmed-article:9714828 | pubmed:affiliation | Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. baker.kevin@gene.com | lld:pubmed |
| pubmed-article:9714828 | pubmed:publicationType | Journal Article | lld:pubmed |
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