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pubmed-article:9714549pubmed:abstractTextWe have investigated the UDP-galactose-4'-epimerase (GALE) enzymatic activity and mRNA expression in the rat mammary gland during lactation. We report a dramatic increase in the GALE enzymatic activity correlated with an increase in the mRNA transcript expression. These results indicate a transcriptional regulation of the enzyme during lactation in the rat mammary gland. Our data are of double interest for further investigation: first, the mammary gland provides a suitable model for the characterisation of the transcriptional regulation elements of GALE which are still unknown in mammals; second, GALE expression could help to compensate UDP-galactose deficiency in classic galactosaemia.lld:pubmed
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pubmed-article:9714549pubmed:authorpubmed-author:ShinY SYSlld:pubmed
pubmed-article:9714549pubmed:authorpubmed-author:PetryK GKGlld:pubmed
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pubmed-article:9714549pubmed:authorpubmed-author:PrestozL LLLlld:pubmed
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pubmed-article:9714549pubmed:pagination391-4lld:pubmed
pubmed-article:9714549pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9714549pubmed:articleTitleDifferential UDP-galactose-4'-epimerase (GALE) enzymatic activity and mRNA expression in the rat mammary gland during lactation.lld:pubmed
pubmed-article:9714549pubmed:affiliationInstitut François Magendie, INSERM U.394 Neurobiologie Intégrative, Bordeaux, France. Prestoz@bordeaux.inserm.frlld:pubmed
pubmed-article:9714549pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9714549pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed