| pubmed-article:9712649 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9712649 | lifeskim:mentions | umls-concept:C1512035 | lld:lifeskim |
| pubmed-article:9712649 | lifeskim:mentions | umls-concept:C0035298 | lld:lifeskim |
| pubmed-article:9712649 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9712649 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:9712649 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:9712649 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:9712649 | pubmed:dateCreated | 1998-9-9 | lld:pubmed |
| pubmed-article:9712649 | pubmed:abstractText | Dopaminergic interplexiform amacrine cells were labeled in transgenic mice with human placental alkaline phosphatase and could therefore be identified after dissociation of the retina and used for whole-cell current and voltage clamp. In absence of synaptic inputs, dopaminergic amacrines spontaneously fired action potentials in a rhythmic pattern. This activity was remarkably robust in the face of inhibition of various voltage-dependent ion channels. It was minimally affected by external cesium or cobalt, suggesting no involvement of either the hyperpolarization-activated cation current Ih or voltage-dependent calcium channels. Inhibiting calcium-activated potassium channels by charybdotoxin or tetraethylammonium slowed the repolarizing phase of the action potentials and eliminated a slow afterhyperpolarization but had a scarce effect on the frequency of spontaneous firing. Voltage-clamp experiments showed that the interspike depolarization leading to threshold results from tetrodotoxin-sensitive sodium channels active at the interspike voltages of -60 to -40 mV. Because dopamine acts on distant targets in the retina, the pacemaker activity of dopaminergic amacrines may be necessary to ensure a tonic release of the modulator from their dendritic tree. Pacemaking is a property that this type of retinal amacrine cell shares with the dopaminergic mesencephalic neurons, but the ionic mechanisms responsible for the spontaneous firing are apparently different. | lld:pubmed |
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| pubmed-article:9712649 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9712649 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9712649 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9712649 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9712649 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:9712649 | pubmed:author | pubmed-author:RaviolaEE | lld:pubmed |
| pubmed-article:9712649 | pubmed:author | pubmed-author:BeanB PBP | lld:pubmed |
| pubmed-article:9712649 | pubmed:author | pubmed-author:GustincichSS | lld:pubmed |
| pubmed-article:9712649 | pubmed:author | pubmed-author:FeigenspanAA | lld:pubmed |
| pubmed-article:9712649 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9712649 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9712649 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9712649 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9712649 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9712649 | pubmed:pagination | 6776-89 | lld:pubmed |
| pubmed-article:9712649 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9712649 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9712649 | pubmed:articleTitle | Spontaneous activity of solitary dopaminergic cells of the retina. | lld:pubmed |
| pubmed-article:9712649 | pubmed:affiliation | Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:9712649 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9712649 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9712649 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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