| pubmed-article:9712471 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9712471 | lifeskim:mentions | umls-concept:C0242295 | lld:lifeskim |
| pubmed-article:9712471 | lifeskim:mentions | umls-concept:C0390643 | lld:lifeskim |
| pubmed-article:9712471 | lifeskim:mentions | umls-concept:C0696758 | lld:lifeskim |
| pubmed-article:9712471 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:9712471 | lifeskim:mentions | umls-concept:C0014479 | lld:lifeskim |
| pubmed-article:9712471 | lifeskim:mentions | umls-concept:C0232478 | lld:lifeskim |
| pubmed-article:9712471 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:9712471 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9712471 | pubmed:dateCreated | 1998-10-16 | lld:pubmed |
| pubmed-article:9712471 | pubmed:abstractText | Nutritional supplements containing Ephedra sinica (ma huang), a botanical source of ephedrine alkaloids, have been linked to several episodes of ephedrine toxicity and at least 17 deaths, yet these products remain unregulated. Ten subjects were enrolled in a randomized, crossover study aimed at characterizing the pharmacokinetics of ephedrine after the ingestion of three commercially available ma huang products compared with a 25-mg ephedrine capsule. Pharmacokinetic parameters for botanical ephedrine were similar to those for synthetic ephedrine hydrochloride. Gender-based comparisons of Vss/F and CL/F revealed higher values for women than for men (Vss/F, 3.49 +/- 1.04 vs 2.98 +/- 0.73 l/kg; CL/F, 0.48 +/- 0.11 vs 0.37 +/- 0.11 l/hour x kg). The current study suggests that the increased incidence of ma huang toxicity does not stem from differences in the absorption of botanical ephedrine compared with synthetic ephedrine; rather, it results from accidental overdose often prompted by exaggerated off-label claims and a belief that "natural" medicinal agents are inherently safe. | lld:pubmed |
| pubmed-article:9712471 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9712471 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9712471 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9712471 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9712471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9712471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9712471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9712471 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9712471 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9712471 | pubmed:issn | 0163-4356 | lld:pubmed |
| pubmed-article:9712471 | pubmed:author | pubmed-author:WinnH EHE | lld:pubmed |
| pubmed-article:9712471 | pubmed:author | pubmed-author:GardnerS FSF | lld:pubmed |
| pubmed-article:9712471 | pubmed:author | pubmed-author:WhiteL MLM | lld:pubmed |
| pubmed-article:9712471 | pubmed:author | pubmed-author:GurleyB JBJ | lld:pubmed |
| pubmed-article:9712471 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9712471 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:9712471 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9712471 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9712471 | pubmed:pagination | 439-45 | lld:pubmed |
| pubmed-article:9712471 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:meshHeading | pubmed-meshheading:9712471-... | lld:pubmed |
| pubmed-article:9712471 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9712471 | pubmed:articleTitle | Ephedrine pharmacokinetics after the ingestion of nutritional supplements containing Ephedra sinica (ma huang). | lld:pubmed |
| pubmed-article:9712471 | pubmed:affiliation | Department of Pharmaceutics, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock 72205, USA. | lld:pubmed |
| pubmed-article:9712471 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9712471 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9712471 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9712471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9712471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9712471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9712471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9712471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9712471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9712471 | lld:pubmed |
