| pubmed-article:9710126 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9710126 | lifeskim:mentions | umls-concept:C1257792 | lld:lifeskim |
| pubmed-article:9710126 | lifeskim:mentions | umls-concept:C1704353 | lld:lifeskim |
| pubmed-article:9710126 | lifeskim:mentions | umls-concept:C0348035 | lld:lifeskim |
| pubmed-article:9710126 | lifeskim:mentions | umls-concept:C1171318 | lld:lifeskim |
| pubmed-article:9710126 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9710126 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9710126 | pubmed:dateCreated | 1998-9-1 | lld:pubmed |
| pubmed-article:9710126 | pubmed:abstractText | Fluid shear stress has been shown to modulate various endothelial functions, including gene expression. In this study, we examined the effect of fluid shear stress on the expression of lectin-like oxidized LDL receptor-1 (LOX-1), a novel receptor for atherogenic oxidized LDL in cultured bovine aortic endothelial cells (BAECs). Exposure of BAECs to the physiological range of shear stress (1 to 15 dyne/cm2) upregulated LOX-1 protein and mRNA in a time-dependent fashion. LOX-1 mRNA levels peaked at 4 hours, and LOX-1 protein levels peaked at 8 hours. Inhibition of de novo RNA synthesis by actinomycin D totally abolished shear stress-induced LOX-1 mRNA expression. Furthermore, nuclear runoff assay showed that shear stress directly stimulates transcription of the LOX-1 gene. Chelation of intracellular Ca2+ with quin 2-AM completely reduced shear stress-induced LOX-1 mRNA expression; furthermore, the treatment of BAECs with ionomycin upregulated LOX-1 mRNA levels in a dose-dependent manner. Taken together, physiological levels of fluid shear stress can regulate LOX-1 expression by a mechanism dependent on intracellular Ca2+ mobilization. Inducible expression of LOX-1 by fluid mechanics may play a role in localized expression of LOX-1 and atherosclerotic lesion formation in vivo. | lld:pubmed |
| pubmed-article:9710126 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9710126 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710126 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9710126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9710126 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9710126 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9710126 | pubmed:issn | 0009-7330 | lld:pubmed |
| pubmed-article:9710126 | pubmed:author | pubmed-author:MasalaCC | lld:pubmed |
| pubmed-article:9710126 | pubmed:author | pubmed-author:KitaTT | lld:pubmed |
| pubmed-article:9710126 | pubmed:author | pubmed-author:AndoJJ | lld:pubmed |
| pubmed-article:9710126 | pubmed:author | pubmed-author:MuraseTT | lld:pubmed |
| pubmed-article:9710126 | pubmed:author | pubmed-author:SawamuraTT | lld:pubmed |
| pubmed-article:9710126 | pubmed:author | pubmed-author:KumeNN | lld:pubmed |
| pubmed-article:9710126 | pubmed:author | pubmed-author:KorenagaRR | lld:pubmed |
| pubmed-article:9710126 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9710126 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:9710126 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:9710126 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9710126 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9710126 | pubmed:pagination | 328-33 | lld:pubmed |
| pubmed-article:9710126 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9710126 | pubmed:meshHeading | pubmed-meshheading:9710126-... | lld:pubmed |
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| pubmed-article:9710126 | pubmed:meshHeading | pubmed-meshheading:9710126-... | lld:pubmed |
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| pubmed-article:9710126 | pubmed:meshHeading | pubmed-meshheading:9710126-... | lld:pubmed |
| pubmed-article:9710126 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9710126 | pubmed:articleTitle | Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells. | lld:pubmed |
| pubmed-article:9710126 | pubmed:affiliation | Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:9710126 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9710126 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9710126 | lld:pubmed |
