| pubmed-article:9705950 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9705950 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:9705950 | lifeskim:mentions | umls-concept:C0035235 | lld:lifeskim |
| pubmed-article:9705950 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:9705950 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:9705950 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9705950 | pubmed:dateCreated | 1998-10-7 | lld:pubmed |
| pubmed-article:9705950 | pubmed:abstractText | Respiratory syncytial virus (RSV) remains a major cause of morbidity and mortality in infants and the elderly and is a continuing challenge for vaccine development. A murine T helper cell (Th) type 2 response associates with enhanced lung pathology, which has been observed in past infant trials using formalin-inactivated RSV vaccine. In this study, we have engineered an optimized plasmid DNA vector expressing the RSV fusion (F) protein (DNA-F). DNA-F was as effective as live RSV in mice at inducing neutralizing antibody and cytotoxic T lymphocyte responses, protection against infection, and high mRNA expression of lung interferon gamma after viral challenge. Furthermore, a DNA-F boost could switch a preestablished anti-RSV Th2 response towards a Th1 response. Critical elements for the optimization of the plasmid constructs included expression of a secretory form of the F protein and the presence of the rabbit beta-globin intron II sequence upstream of the F-encoding sequence. In addition, anti-F systemic immune response profile could be modulated by the route of DNA-F delivery: intramuscular immunization resulted in balanced responses, whereas intradermal immunization resulted in a Th2 type of response. Thus, DNA-F immunization may provide a novel and promising RSV vaccination strategy. | lld:pubmed |
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| pubmed-article:9705950 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9705950 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9705950 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9705950 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9705950 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9705950 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:KleinMM | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:JamesOO | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:LULL | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:EwasyshynMM | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:LiC XCX | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:SambharaSS | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:DuR PRP | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:ParringtonMM | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:CatesGG | lld:pubmed |
| pubmed-article:9705950 | pubmed:author | pubmed-author:CateriniJJ | lld:pubmed |
| pubmed-article:9705950 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9705950 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:9705950 | pubmed:volume | 188 | lld:pubmed |
| pubmed-article:9705950 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9705950 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9705950 | pubmed:pagination | 681-8 | lld:pubmed |
| pubmed-article:9705950 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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