| pubmed-article:9695959 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9695959 | lifeskim:mentions | umls-concept:C0680220 | lld:lifeskim |
| pubmed-article:9695959 | lifeskim:mentions | umls-concept:C0796355 | lld:lifeskim |
| pubmed-article:9695959 | lifeskim:mentions | umls-concept:C0368761 | lld:lifeskim |
| pubmed-article:9695959 | lifeskim:mentions | umls-concept:C1961099 | lld:lifeskim |
| pubmed-article:9695959 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9695959 | lifeskim:mentions | umls-concept:C1709305 | lld:lifeskim |
| pubmed-article:9695959 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9695959 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9695959 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9695959 | pubmed:dateCreated | 1998-8-18 | lld:pubmed |
| pubmed-article:9695959 | pubmed:abstractText | The TAL1 gene is disrupted by translocation or deletion (tal(d)) in up to 30% of T-cell acute lymphoblastic leukaemia (T-ALL), leading to aberrant transcriptional activation, as a SIL-TAL1 fused transcript in tal(d). It has been suggested that TAL1 transcription occurs in approximately 50% of a T-ALLs without apparent rearrangement. SIL-TAL1 was positive in 15/60 (25%) of T-ALL, whereas wild-type TAL1 transcripts were detected in all 13 SIL-TAL1 and in 19/43 (44%) T-ALL without SIL-TAL1. To investigate the cellular origin of TAL1 we exploited the fact that GATA1 and TAL1 are co-ordinately expressed in non-lymphoid haemopoietic cells, whereas only the latter is found in T-ALL. GATA1 was detected in 10/23 (43%) TAL1-negative T-ALLs but in 17/19 (89%) 'unexplained' TAL1-positive cases, suggesting a common non-lymphoid cellular origin. Immunocytochemical analysis with a TAL1-specific monoclonal antibody showed nuclear expression in the blasts of 10/34 (29%) cases, including 8/10 SIL-TAL1+ and two RT-PCR TAL1+, SIL-TAL1- cases. In the remaining cases TAL1 expression was restricted to a minor population (< 5%) of larger, strongly TAL1-positive cells which comprised erythroid cells, CD34+ CD3- precursors and an unidentified TAL1+ CD45- population which morphologically resembled monocytes/macrophages. We therefore suggest that appropriate diagnostic evaluation of T-ALL should include molecular detection of SIL-TAL1 transcripts and in situ immunocytochemical detection of TAL1 protein expression by leukaemic blasts. This approach will enable accurate analysis of the prognostic significance of TAL1 deregulation in T-ALL. | lld:pubmed |
| pubmed-article:9695959 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9695959 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9695959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9695959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9695959 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9695959 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:StromingerJ... | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:MeyerVV | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:RitzJJ | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:ValensiFF | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:BourquelotPP | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:BernardMM | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:SmitLL | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:MacintyreE... | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:PulfordKK | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:CayuelaJ MJM | lld:pubmed |
| pubmed-article:9695959 | pubmed:author | pubmed-author:DelabesseEE | lld:pubmed |
| pubmed-article:9695959 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9695959 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:9695959 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9695959 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9695959 | pubmed:pagination | 449-57 | lld:pubmed |
| pubmed-article:9695959 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9695959 | pubmed:meshHeading | pubmed-meshheading:9695959-... | lld:pubmed |
| pubmed-article:9695959 | pubmed:meshHeading | pubmed-meshheading:9695959-... | lld:pubmed |
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| pubmed-article:9695959 | pubmed:meshHeading | pubmed-meshheading:9695959-... | lld:pubmed |
| pubmed-article:9695959 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9695959 | pubmed:articleTitle | TAL1 expression does not occur in the majority of T-ALL blasts. | lld:pubmed |
| pubmed-article:9695959 | pubmed:affiliation | CNRS URA 1461 and Department of Haematology, CHU Necker-Enfants Malades and Université Paris V, France. | lld:pubmed |
| pubmed-article:9695959 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9695959 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9695959 | lld:pubmed |
