| pubmed-article:9694868 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9694868 | lifeskim:mentions | umls-concept:C0020094 | lld:lifeskim |
| pubmed-article:9694868 | lifeskim:mentions | umls-concept:C0663914 | lld:lifeskim |
| pubmed-article:9694868 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:9694868 | lifeskim:mentions | umls-concept:C0249854 | lld:lifeskim |
| pubmed-article:9694868 | pubmed:issue | 33 | lld:pubmed |
| pubmed-article:9694868 | pubmed:dateCreated | 1998-9-14 | lld:pubmed |
| pubmed-article:9694868 | pubmed:abstractText | The tax gene product of human T-cell leukemia virus I induces aberrant expression of various cellular genes, which contributes to transformation of host cells. Induction of many Tax target genes is mediated through transcription factor NF-kappaB. Here we show that Tax triggers activation of cellular protein kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta, which phosphorylate the NF-kappaB inhibitory protein IkappaB alpha, resulting in its degradation and NF-kappaB activation. Constitutive IKK activation occurs in both Tax-transfected and human T-cell leukemia virus I-infected T cells. We further demonstrate that Tax-mediated NF-kappaB signaling also requires the NF-kappaB-inducing kinase (NIK). Consistently, inactive forms of either IKKs or NIK attenuate Tax-mediated NF-kappaB activation. Therefore, Tax activates NF-kappaB by targeting cellular signaling molecules, including both IKKs and NIK. | lld:pubmed |
| pubmed-article:9694868 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9694868 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9694868 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9694868 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9694868 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9694868 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9694868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9694868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9694868 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9694868 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9694868 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9694868 | pubmed:author | pubmed-author:SunS CSC | lld:pubmed |
| pubmed-article:9694868 | pubmed:author | pubmed-author:KarinMM | lld:pubmed |
| pubmed-article:9694868 | pubmed:author | pubmed-author:GoodLL | lld:pubmed |
| pubmed-article:9694868 | pubmed:author | pubmed-author:UhligAA | lld:pubmed |
| pubmed-article:9694868 | pubmed:author | pubmed-author:ZandaMM | lld:pubmed |
| pubmed-article:9694868 | pubmed:author | pubmed-author:XiaoGG | lld:pubmed |
| pubmed-article:9694868 | pubmed:author | pubmed-author:HarhajE WEW | lld:pubmed |
| pubmed-article:9694868 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9694868 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:9694868 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9694868 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9694868 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9694868 | pubmed:pagination | 21132-6 | lld:pubmed |
| pubmed-article:9694868 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
| pubmed-article:9694868 | pubmed:meshHeading | pubmed-meshheading:9694868-... | lld:pubmed |
| pubmed-article:9694868 | pubmed:meshHeading | pubmed-meshheading:9694868-... | lld:pubmed |
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| pubmed-article:9694868 | pubmed:meshHeading | pubmed-meshheading:9694868-... | lld:pubmed |
| pubmed-article:9694868 | pubmed:meshHeading | pubmed-meshheading:9694868-... | lld:pubmed |
| pubmed-article:9694868 | pubmed:meshHeading | pubmed-meshheading:9694868-... | lld:pubmed |
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| pubmed-article:9694868 | pubmed:meshHeading | pubmed-meshheading:9694868-... | lld:pubmed |
| pubmed-article:9694868 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9694868 | pubmed:articleTitle | NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. | lld:pubmed |
| pubmed-article:9694868 | pubmed:affiliation | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. | lld:pubmed |
| pubmed-article:9694868 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9694868 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9694868 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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