| pubmed-article:9688535 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9688535 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:9688535 | lifeskim:mentions | umls-concept:C0205242 | lld:lifeskim |
| pubmed-article:9688535 | lifeskim:mentions | umls-concept:C0081487 | lld:lifeskim |
| pubmed-article:9688535 | lifeskim:mentions | umls-concept:C0623362 | lld:lifeskim |
| pubmed-article:9688535 | lifeskim:mentions | umls-concept:C0919336 | lld:lifeskim |
| pubmed-article:9688535 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:9688535 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:9688535 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:9688535 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:9688535 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9688535 | pubmed:dateCreated | 1998-8-13 | lld:pubmed |
| pubmed-article:9688535 | pubmed:abstractText | An aggrecan G1-G2 substrate was used to determine sites within the interglobular domain that were susceptible to cleavage by MT1-MMP. Degradation products were identified by Western blotting with neo-epitope antibodies specific for MMP-derived N- and C-terminal sequences. The results showed that MT1-MMP cleaved at the N341-F342 and D441-L442 bonds, as shown for other MMPs, and also at a site 13 amino acids C-terminal to the N341-F342 site. The G2 product of this additional cleavage was identified by sequence analysis and revealed an N-terminus commencing T355VxxPDVELPLP. The data are consistent with MT1-MMP cleavage at three sites in the aggrecan interglobular domain; one at N342-F342, a second at D441-L442 and a third at Q354-T355. | lld:pubmed |
| pubmed-article:9688535 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9688535 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9688535 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9688535 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9688535 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:9688535 | pubmed:author | pubmed-author:OkadaYY | lld:pubmed |
| pubmed-article:9688535 | pubmed:author | pubmed-author:FujiiYY | lld:pubmed |
| pubmed-article:9688535 | pubmed:author | pubmed-author:SeikeII | lld:pubmed |
| pubmed-article:9688535 | pubmed:author | pubmed-author:GüssHH | lld:pubmed |
| pubmed-article:9688535 | pubmed:author | pubmed-author:FosangA JAJ | lld:pubmed |
| pubmed-article:9688535 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9688535 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:9688535 | pubmed:volume | 430 | lld:pubmed |
| pubmed-article:9688535 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9688535 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9688535 | pubmed:pagination | 186-90 | lld:pubmed |
| pubmed-article:9688535 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9688535 | pubmed:meshHeading | pubmed-meshheading:9688535-... | lld:pubmed |
| pubmed-article:9688535 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9688535 | pubmed:articleTitle | Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain. | lld:pubmed |
| pubmed-article:9688535 | pubmed:affiliation | Orthopaedic Molecular Biology Research Unit, Melbourne University, Royal Children's Hospital, Parkville, Australia. fosang@cryptic.rch.unimelb.edu.au | lld:pubmed |
| pubmed-article:9688535 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9688535 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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