| pubmed-article:9685328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9685328 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9685328 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9685328 | lifeskim:mentions | umls-concept:C0038323 | lld:lifeskim |
| pubmed-article:9685328 | lifeskim:mentions | umls-concept:C0057738 | lld:lifeskim |
| pubmed-article:9685328 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:9685328 | lifeskim:mentions | umls-concept:C0661253 | lld:lifeskim |
| pubmed-article:9685328 | lifeskim:mentions | umls-concept:C0764092 | lld:lifeskim |
| pubmed-article:9685328 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:9685328 | pubmed:dateCreated | 1998-9-10 | lld:pubmed |
| pubmed-article:9685328 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:abstractText | Diazepam-binding inhibitor/acyl-CoA-binding protein (DBI/ACBP), a highly conserved 10-kDa polypeptide, has been implicated in various physiological processes including gamma-aminobutyric acid type A receptor binding, acyl-CoA binding and transport, steroidogenesis, and peptide hormone release. Both in LNCaP prostate cancer cells and 3T3-L1 preadipocytes, the expression of DBI/ACBP is stimulated under conditions that promote lipogenesis (treatment with androgens and insulin, respectively) and that involve the activation of sterol regulatory element-binding proteins (SREBPs). Accordingly, we investigated whether DBI/ACBP expression is under the direct control of SREBPs. Analysis of the human and rat DBI/ACBP promoter revealed the presence of a conserved sterol regulatory element (SRE)-like sequence. Gel shift analysis confirmed that this sequence is able to bind SREBPs. In support of the functionality of SREBP binding, coexpression of SREBP-1a with a DBI/ACBP promoter-reporter gene resulted in a 50-fold increase in transcriptional activity in LNCaP cells. Disruption of the SRE decreased basal expression and abolished SREBP-1a-induced transcriptional activation. In agreement with the requirement of a co-regulator for SREBP function, transcriptional activation by SREBP-1a overexpression was severely diminished when a neighboring NF-Y site was mutated. Cholesterol depletion or androgen treatment, conditions that activate SREBP function in LNCaP cells, led to an increase in DBI/ACBP mRNA expression and SRE-dependent transcriptional activation. These findings indicate that the promoter for DBI/ACBP contains a functional SRE that allows DBI/ACBP to be coregulated with other genes involved in lipid metabolism. | lld:pubmed |
| pubmed-article:9685328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9685328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9685328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9685328 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9685328 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9685328 | pubmed:author | pubmed-author:HeynsWW | lld:pubmed |
| pubmed-article:9685328 | pubmed:author | pubmed-author:VerhoevenGG | lld:pubmed |
| pubmed-article:9685328 | pubmed:author | pubmed-author:AldyDD | lld:pubmed |
| pubmed-article:9685328 | pubmed:author | pubmed-author:SwinnenJ VJV | lld:pubmed |
| pubmed-article:9685328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9685328 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:9685328 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9685328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9685328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9685328 | pubmed:pagination | 19938-44 | lld:pubmed |
| pubmed-article:9685328 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9685328 | pubmed:meshHeading | pubmed-meshheading:9685328-... | lld:pubmed |
| pubmed-article:9685328 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9685328 | pubmed:articleTitle | Identification of diazepam-binding Inhibitor/Acyl-CoA-binding protein as a sterol regulatory element-binding protein-responsive gene. | lld:pubmed |
| pubmed-article:9685328 | pubmed:affiliation | Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, B-3000 Leuven, Belgium. johan.swinnen@med.kuleuven.ac.be | lld:pubmed |
| pubmed-article:9685328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9685328 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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