| pubmed-article:9683429 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9683429 | lifeskim:mentions | umls-concept:C0036226 | lld:lifeskim |
| pubmed-article:9683429 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:9683429 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:9683429 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:9683429 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:9683429 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:9683429 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:9683429 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:9683429 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:9683429 | pubmed:issue | 2 Pt 2 | lld:pubmed |
| pubmed-article:9683429 | pubmed:dateCreated | 1998-9-16 | lld:pubmed |
| pubmed-article:9683429 | pubmed:abstractText | The effect of Cs+ on the function of the cardiac sarcoplasmic reticulum (SR) has been investigated in skinned cardiac myocytes. Isolated rat ventricular myocytes were permeabilized using saponin and then perfused with a solution containing 150 nmol/l Ca2+ and 10 micromol/l fura 2. Fura 2 fluorescence from the skinned cell was monitored to assess SR Ca2+ release. The frequency of spontaneous Ca2+ release from the SR decreased when K+ in the bathing solution was completely replaced with Cs+. Cs+ had little effect on the amplitude of spontaneous release but prolonged both the rise time and decay time. The SR Ca2+ content, assessed by application of caffeine, was reduced in the Cs+ solution. Cyclopiazonic acid produced effects similar to those of Cs+. Extracellular Cs+ (20 mmol/l) increased the amplitude of the Ca2+ transient and the SR Ca2+ content in intact field-stimulated cells but had little effect on the Ca2+ transient when the amplitude and duration of depolarization were kept constant using voltage clamp. These data suggest that Cs+ slows Ca2+ movement across the SR membrane, possibly by blocking the SR K+ channel, but has additional effects in intact cells that overcome its inhibitory effects on the SR. | lld:pubmed |
| pubmed-article:9683429 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9683429 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9683429 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9683429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9683429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9683429 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9683429 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9683429 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9683429 | pubmed:author | pubmed-author:KawaiMM | lld:pubmed |
| pubmed-article:9683429 | pubmed:author | pubmed-author:HussainMM | lld:pubmed |
| pubmed-article:9683429 | pubmed:author | pubmed-author:OrchardC HCH | lld:pubmed |
| pubmed-article:9683429 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9683429 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:9683429 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9683429 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9683429 | pubmed:pagination | H422-30 | lld:pubmed |
| pubmed-article:9683429 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9683429 | pubmed:meshHeading | pubmed-meshheading:9683429-... | lld:pubmed |
| pubmed-article:9683429 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9683429 | pubmed:articleTitle | Cs+ inhibits spontaneous Ca2+ release from sarcoplasmic reticulum of skinned cardiac myocytes. | lld:pubmed |
| pubmed-article:9683429 | pubmed:affiliation | Department of Physiology, University of Leeds, Leeds LS2 9NQ, United Kingdom. | lld:pubmed |
| pubmed-article:9683429 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9683429 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9683429 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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