| pubmed-article:9670055 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
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| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C0245662 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C0004359 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C1705955 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C1257986 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9670055 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:9670055 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9670055 | pubmed:dateCreated | 1998-8-11 | lld:pubmed |
| pubmed-article:9670055 | pubmed:abstractText | Recently, we demonstrated that major histocompatibility complex class I-restricted cross-presentation of exogenous self-antigens can induce peripheral T cell tolerance by deletion of autoreactive CD8+ T cells. In these studies, naive ovalbumin (OVA)-specific CD8+ T cells from the transgenic line OT-I were injected into transgenic mice expressing membrane-bound OVA (mOVA) under the control of the rat insulin promoter (RIP) in pancreatic islets, kidney proximal tubules, and the thymus. Cross-presentation of tissue-derived OVA in the renal and pancreatic lymph nodes resulted in activation, proliferation, and then the deletion of OT-I cells. In this report, we investigated the molecular mechanisms underlying this form of T cell deletion. OT-I mice were crossed to tumor necrosis factor receptor 2 (TNFR2) knockout mice and to CD95 (Fas, Apo-1) deficient mutant lpr mice. Wild-type and TNFR2-deficient OT-I cells were activated and then deleted when transferred into RIP-mOVA mice, whereas CD95-deficient OT-I cells were not susceptible to deletion by cross-presentation. Furthermore, cross-presentation led to upregulation of the CD95 molecule on the surface of wild-type OT-I cells in vivo, consistent with the idea that this is linked to rendering autoreactive T cells susceptible to CD95-mediated signaling. This study represents the first evidence that CD95 is involved in the deletion of autoreactive CD8+ T cells in the whole animal. | lld:pubmed |
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| pubmed-article:9670055 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9670055 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9670055 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9670055 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9670055 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9670055 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9670055 | pubmed:author | pubmed-author:MillerJ FJF | lld:pubmed |
| pubmed-article:9670055 | pubmed:author | pubmed-author:KosakaHH | lld:pubmed |
| pubmed-article:9670055 | pubmed:author | pubmed-author:KurtzJJ | lld:pubmed |
| pubmed-article:9670055 | pubmed:author | pubmed-author:CarboneF RFR | lld:pubmed |
| pubmed-article:9670055 | pubmed:author | pubmed-author:HeathW RWR | lld:pubmed |
| pubmed-article:9670055 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9670055 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:9670055 | pubmed:volume | 188 | lld:pubmed |
| pubmed-article:9670055 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9670055 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9670055 | pubmed:pagination | 415-20 | lld:pubmed |
| pubmed-article:9670055 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9670055 | pubmed:meshHeading | pubmed-meshheading:9670055-... | lld:pubmed |
| pubmed-article:9670055 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9670055 | pubmed:articleTitle | The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). | lld:pubmed |
| pubmed-article:9670055 | pubmed:affiliation | Immunology Division of The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia. | lld:pubmed |
| pubmed-article:9670055 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9670055 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9670055 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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