Linked Life Data

9669385

Source:http://linkedlifedata.com/resource/pubmed/id/9669385

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pubmed-article:9669385pubmed:abstractTextGlial neoplasms of the human central nervous system have defied treatment, in part because of the limited selectivity of available cytotoxic agents. The thymidine analog 5-iodo-2'-deoxyuridine radiolabeled with the Auger electron emitter 125I (125IUdR) is highly toxic to dividing cells when it is deoxyribonucleic acid incorporated, but it is relatively innocuous when located outside the nucleus. Previous studies have shown that 125IUdR has significant antineoplastic potential against mammalian cells in vitro and direct administration of 125IUdR is effective therapy for ovarian ascites tumors in mice and neoplastic meningitis in rats. Studies using external gamma imaging and autoradiography have also shown that direct intratumoral administration of 123IUdR/125IUdR into intracerebral 9L gliosarcomas in rats results in selective uptake of the radionuclide into tumor cells. Based on these encouraging results, we have evaluated the therapeutic potential of 125IUdR in rats bearing intracerebral 9L gliosarcomas.lld:pubmed
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pubmed-article:9669385pubmed:articleTitle5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats.lld:pubmed
pubmed-article:9669385pubmed:affiliationDepartment of Radiology, Harvard Medical School, Boston, Massachusetts 02115, USA.lld:pubmed
pubmed-article:9669385pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9669385pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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