| pubmed-article:9668039 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9668039 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9668039 | lifeskim:mentions | umls-concept:C0001271 | lld:lifeskim |
| pubmed-article:9668039 | lifeskim:mentions | umls-concept:C0248813 | lld:lifeskim |
| pubmed-article:9668039 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:9668039 | lifeskim:mentions | umls-concept:C0162657 | lld:lifeskim |
| pubmed-article:9668039 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9668039 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9668039 | pubmed:issue | 30 | lld:pubmed |
| pubmed-article:9668039 | pubmed:dateCreated | 1998-8-20 | lld:pubmed |
| pubmed-article:9668039 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9668039 | pubmed:abstractText | We purified from rat brain a novel F-actin-binding protein with a Mr of about 105,000 (p105), which was estimated by SDS-polyacrylamide gel electrophoresis. We cloned its cDNA from a rat brain cDNA library and characterized it. p105 was a protein of 766 amino acids and showed a calculated Mr of 86,449. p105 consisted of one F-actin-binding domain at the N-terminal region, one Dbl homology domain and one pleckstrin homology domain at the middle region, and one cysteine-rich domain at the C-terminal region. This domain organization of p105 was similar to that of FGD1, which has been determined to be the genetic locus responsible for faciogenital dysplasia or Aarskog-Scott syndrome. We therefore named p105 frabin (FGD1-related F-actin-binding protein). Frabin bound along the sides of F-actin and showed F-actin-cross-linking activity. Overexpression of frabin in Swiss 3T3 cells and COS7 cells induced cell shape change and c-Jun N-terminal kinase activation, respectively, as described for FGD1. Because FGD1 has been shown to serve as a GDP/GTP exchange protein for Cdc42 small G protein, it is likely that frabin is a direct linker between Cdc42 and the actin cytoskeleton. | lld:pubmed |
| pubmed-article:9668039 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9668039 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9668039 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9668039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9668039 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9668039 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9668039 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:TakahashiKK | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:MiyaharaMM | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:TakaiYY | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:NakanishiHH | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:SatohKK | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:SatohAA | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:NishiokaHH | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:TakaishiKK | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:MandaiKK | lld:pubmed |
| pubmed-article:9668039 | pubmed:author | pubmed-author:ObaishiHH | lld:pubmed |
| pubmed-article:9668039 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9668039 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:9668039 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9668039 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9668039 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9668039 | pubmed:pagination | 18697-700 | lld:pubmed |
| pubmed-article:9668039 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9668039 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9668039 | pubmed:articleTitle | Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. | lld:pubmed |
| pubmed-article:9668039 | pubmed:affiliation | Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c/o JCR Pharmaceuticals Co., Ltd., 2-2-10 Murotani, Nishi-ku, Kobe 651-2241, Japan. | lld:pubmed |
| pubmed-article:9668039 | pubmed:publicationType | Journal Article | lld:pubmed |
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