| pubmed-article:9662614 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9662614 | lifeskim:mentions | umls-concept:C0085490 | lld:lifeskim |
| pubmed-article:9662614 | lifeskim:mentions | umls-concept:C1510458 | lld:lifeskim |
| pubmed-article:9662614 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:9662614 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:9662614 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:9662614 | lifeskim:mentions | umls-concept:C0449444 | lld:lifeskim |
| pubmed-article:9662614 | lifeskim:mentions | umls-concept:C1518896 | lld:lifeskim |
| pubmed-article:9662614 | lifeskim:mentions | umls-concept:C1112870 | lld:lifeskim |
| pubmed-article:9662614 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9662614 | pubmed:dateCreated | 1998-8-13 | lld:pubmed |
| pubmed-article:9662614 | pubmed:abstractText | Positive control 1 (PC1) (n = 9) goats were injected transthoracically into the left lung with live Pasteurella haemolytica biovar A, serovar 1 (PhA1) in polyacrylate (PA) beads on days 0 and 21. Positive control 2 (PC2) (n = 6) goats were nebulized with live PhA1 and PA beads on days 0 and 21. Negative control (NC) goats (n = 6) were each injected transthoracically into the left lung with PA beads alone on days 0 and 21. Four groups (n = 6) were administered PA beads mixed with ultraviolet (UV) killed PhA1 on days 0 and 21. The treatment doses of bacteria for these groups were principal group 1 (PR1) injected into the left lung (7.7 x 10(10) cfu); PR2, 7.7 x 10(10) UV-killed PhA1 injected subcutaneously (SC); PR3, 7.7 x 10(10) UV-killed PhA1 injected SC only on day 21; PR4, nebulized with PA beads mixed with 5.6 x 10(10) cfu of UV-killed PhA1; and PR5, nebulized with PA beads mixed with 5 x 10(8) cfu of UV-killed PhA1. All goats were challenged transthoracically in the right lung with 1 x 10(8) cfu of live PhA1 on day 42 and necropsied on day 46. The sizes of consolidated lung lesions at the challenge site were used as a measure of immunity. The data show that the introduction of live PhA1 into the lungs of goats, either by injection or aerosolization, offers excellent protection against a subsequent homologous challenge. The data also demonstrate that two transthoracic injections (21 days apart) of UV-killed PhA1 (PR1), and subcutaneous injection of UV-killed PhA1(PR2) also offer excellent protection against a subsequent homologous live PhA1 challenge. One SC injection of UV-killed PhA1 (PR3) appears to offer only partial protection against a subsequent homologous live PhA1 challenge. Inhalation of UV-killed PhA1 mixed with PA beads (PR4 and PR5) induced no protection in goats against a subsequent live PhA1 transthoracic challenge. | lld:pubmed |
| pubmed-article:9662614 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9662614 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9662614 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9662614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9662614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9662614 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9662614 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9662614 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9662614 | pubmed:issn | 0343-8651 | lld:pubmed |
| pubmed-article:9662614 | pubmed:author | pubmed-author:StrausD CDC | lld:pubmed |
| pubmed-article:9662614 | pubmed:author | pubmed-author:PurdyC WCW | lld:pubmed |
| pubmed-article:9662614 | pubmed:author | pubmed-author:CooleyJ DJD | lld:pubmed |
| pubmed-article:9662614 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9662614 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:9662614 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9662614 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9662614 | pubmed:pagination | 132-6 | lld:pubmed |
| pubmed-article:9662614 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
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| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:meshHeading | pubmed-meshheading:9662614-... | lld:pubmed |
| pubmed-article:9662614 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9662614 | pubmed:articleTitle | Pasteurella haemolytica ultraviolet-irradiated vaccine by parenteral and aerosol routes compared in the goat model. | lld:pubmed |
| pubmed-article:9662614 | pubmed:affiliation | Conservation and Production Research Laboratory, USDA Agriculture Research Service, Bushland, TX 79012, USA. | lld:pubmed |
| pubmed-article:9662614 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9662614 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9662614 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
