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pubmed-article:9662470pubmed:abstractTextThe control of insects that transmit disease and damage crops has become increasingly difficult. The ability to genetically engineer insects would facilitate strategies to protect crops and block arthropod vector-borne disease transmission. Transformation vectors based on insect transposable elements have been developed, but most have limited host ranges. A promising alternative is the pantropic retroviral vector, which is packaged with the envelope glycoprotein from vesicular stomatitis virus and is replication-defective. We show here that pantropic murine retroviral vectors can mediate high-level expression of foreign genes in somatically transformed insect larvae and adults of three dipteran genera. This success demonstrates the potential for germline transformation mediated by pantropic retroviral vectors.lld:pubmed
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pubmed-article:9662470pubmed:pagination215-22lld:pubmed
pubmed-article:9662470pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9662470pubmed:year1998lld:pubmed
pubmed-article:9662470pubmed:articleTitlePantropic retroviral vectors mediate somatic cell transformation and expression of foreign genes in dipteran insects.lld:pubmed
pubmed-article:9662470pubmed:affiliationDepartment of Biology, University of California, Riverside, USA.lld:pubmed
pubmed-article:9662470pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9662470pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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