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pubmed-article:9661988pubmed:abstractTextMice of the CXB recombinant inbred (RI) panel were phenotyped for period of locomotor activity in continuous dark (tau) and in continuous 10-lux light (tauLL). There were significant differences in the effect of light on period, delta tau (tauLL-tau), among CXB RI strains and their progenitors. By comparing strain means for delta tau in the CXB RI strains with typed genetic loci using a product moment correlation, it was possible to hypothesize quantitative trait loci (QTL) important to the genetic variance in the effect of constant low-level light on circadian period. Some of the candidate genes linked to statistically associated markers are neuropharmacologically interesting. Provisional QTL for delta tau were found on proximal Chromosome 8 and mid Chromosome 11 in regions near QTL identified in a similar analysis of the BXD RI panel. This provides additional evidence for the importance of loci on Chromosomes 8 and 11.lld:pubmed
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pubmed-article:9661988pubmed:authorpubmed-author:MayedaA RARlld:pubmed
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pubmed-article:9661988pubmed:volume64lld:pubmed
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pubmed-article:9661988pubmed:year1998lld:pubmed
pubmed-article:9661988pubmed:articleTitleProvisional quantitative trait loci (QTL) for the Aschoff effect in RI mice.lld:pubmed
pubmed-article:9661988pubmed:affiliationRoudebush VA Medical Center, Department of Veteran Affairs, Indianapolis, IN 46202, USA. JHOFSTET@iupui.edulld:pubmed
pubmed-article:9661988pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9661988pubmed:publicationTypeComparative Studylld:pubmed
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